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Benzensulfonamider

Organiske forbindelser, der består af en benzenring substitueret med en sulfonylgruppe, der efterfølgende er bundet til en aminogruppe; betragtes som amidet af benzensulfonsyre.

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1 – 15 af 235 Resultater
1

NXT629, MedChemExpress

MedChemExpress NXT629 is a potent, selective, and competitive PPAR-α antagonist, with an IC50 of 77 nM for human PPARα, shows high selectivity over other nuclear hormone receptor, such as PPARδ, PPARγ, ERβ, GR and TRβ, IC50s are 6.0, 15, 15.2, 32.5 and >100 μM, respectively. NXT629 has potent anti-tumor activity and inhibits experimental metastasis of cancer cell in animal models.

ENCOMPASS_PREFERRED
Kemisk navn eller materiale NXT629
Formel vægt 609.78
Opløselighedsinformation DMSO : 125 mg/mL (204.99 mM; Need ultrasonic)
Procent renhed 99.2%
Fysisk form Solid
Farve Light Yellow
Grad Research
Anbefalet opbevaring Powder -20°C 3 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol) 609.78
CAS 1454925-59-7
Holdbarhed Powder -20°C 3 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL O=S(C1=CC=CC=C1)(NC2=CC=C(C3=CC=C(CCCC(N4CC)=NN(CC5=CC=C(C(C)(C)C)C=C5)C4=O)C=C3)N=C2)=O
Renhedsgrad noter Research
Molekylær formel C35H39N5O3S
Til brug med (applikation) Cancer-programmed cell death
2

Orexin 2 Receptor Agonist, MedChemExpress

MedChemExpress Orexin 2 Receptor Agonist is a potent (EC50 on OX2R is 23 nM) and OX2R-selective (OX1R/OX2R EC50 ratio is 70) agonist.

ENCOMPASS_PREFERRED
Kemisk navn eller materiale Orexin 2 Receptor Agonist
Formel vægt 586.7
Opløselighedsinformation DMSO : ≥ 32 mg/mL (54.54 mM)
Procent renhed 99.75%
Fysisk form Solid
Farve White
Grad Research
Anbefalet opbevaring Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol) 586.7
CAS 1796565-52-0
Holdbarhed Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL O=C(C1=CC=CC(C)=C1)NCCNC2=CC(NS(C3=C(OC)C=CC(C4=CC(C(N(C)C)=O)=CC=C4)=C3)(=O)=O)=CC=C2
Renhedsgrad noter Research
Molekylær formel C32H34N4O5S
Til brug med (applikation) Neuroscience-Neuromodulation
3

LX2343, MedChemExpress

MedChemExpress LX2343 is a BACE1 enzyme inhibitor with an IC50 value of 11.43±0.36 μM. LX2343 acts as a non-ATP competitive PI3K inhibitor with an IC50 of 15.99±3.23 μM. LX2343 stimulates autophagy in its promotion of Aβ clearance.

ENCOMPASS_PREFERRED
Kemisk navn eller materiale LX2343
Formel vægt 474.91
Opløselighedsinformation DMSO : ≥ 100 mg/mL (210.57 mM)
Procent renhed 99.74%
Fysisk form Solid
Farve White
Grad Research
Anbefalet opbevaring Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol) 474.91
CAS 333745-53-2
Holdbarhed Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL O=C(NC1=CC=C(OCO2)C2=C1)CN(C3=CC(Cl)=CC=C3OC)S(=O)(C4=CC=CC=C4)=O
Renhedsgrad noter Research
Molekylær formel C22H19ClN2O6S
Til brug med (applikation) Neuroscience-Neurodegeneration
4

Acetohexamide, MedChemExpress

MedChemExpress Acetohexamide is a first-generation sulfonylurea medication used to treat diabetes mellitus type 2; stimulate the pancreas to secrete insulin.

ENCOMPASS_PREFERRED
Kemisk navn eller materiale Acetohexamide
Formel vægt 324.4
Opløselighedsinformation DMSO : 25 mg/mL (77.07 mM; Need ultrasonic)
Procent renhed 99.39%
Fysisk form Solid
Farve White
Grad Research
Anbefalet opbevaring Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol) 324.4
CAS 968-81-0
Holdbarhed Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL O=S(C1=CC=C(C(C)=O)C=C1)(NC(NC2CCCCC2)=O)=O
Renhedsgrad noter Research
Molekylær formel C15H20N2O4S
Til brug med (applikation) Cancer-programmed cell death
5

L755507, MedChemExpress

MedChemExpress L755507 is a potent, selective agonist of β3-AR with an IC50 of 35 nM. L755507 enhances the homology-directed repair (HDR)-mediated genome editing in CRISPR/Cas9 nickase system.

ENCOMPASS_PREFERRED
6

PKR-IN-2, MedChemExpress

MedChemExpress PKR-IN-2 is a pyruvate kinase isoform PKR activator extracted from patent WO2014139144A1, compound 160. PKR-IN-2 can be used for the research of PKR function related diseases, including cancer, diabetes, obesity, autoimmune disorders, and benign prostatic hyperplasia.

ENCOMPASS_PREFERRED
Kemisk navn eller materiale PKR-IN-2
Formel vægt 468.57
Opløselighedsinformation DMSO : 50 mg/mL (106.71 mM; Need ultrasonic)
Procent renhed 95.14%
Fysisk form Solid
Farve White
Grad Research
Anbefalet opbevaring Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol) 468.57
CAS 1628428-01-2
Holdbarhed Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL N1C2C(=C(S(NC3=CC=C(C(N4CCC(O)(CC(C)C)CC4)=O)C=C3)(=O)=O)C=CC=2)N=CC=1
Renhedsgrad noter Research
Molekylær formel C24H28N4O4S
Til brug med (applikation) Cancer-Kinase/protease
7

Hydroxyhexamide, MedChemExpress

MedChemExpress Hydroxyhexamide is a pharmacologically active metabolite of Acetohexamide, used as a hypoglycemic agents.

ENCOMPASS_PREFERRED
Kemisk navn eller materiale Hydroxyhexamide
Formel vægt 326.41
Opløselighedsinformation DMSO : ≥ 300 mg/mL (919.09 mM)
Procent renhed 99.68%
Fysisk form Solid
Farve White
Grad Research
Anbefalet opbevaring Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol) 326.41
CAS 3168-01-2
Synonym (±)-Hydroxyhexamid
Holdbarhed Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL O=S(C1=CC=C(C(O)C)C=C1)(NC(NC2CCCCC2)=O)=O
Renhedsgrad noter Research
Molekylær formel C15H22N2O4S
Til brug med (applikation) COVID-19-immunoregulation
8

Etebenecid, MedChemExpress

MedChemExpress Etebenecid is a uricosuric agents, lower uric acid levels in the body by increasing the elimination of uric acid by the kidneys, also inhibits penicillin tubular secretion.

ENCOMPASS_PREFERRED
9

Sulfamethoxypyridazine, MedChemExpress

MedChemExpress Sulfamethoxypyridazine is a long-acting sulfonamide antibiotic, for treatment of Dermatitis herpetiformis.

ENCOMPASS_PREFERRED
10

SU11274, MedChemExpress

MedChemExpress SU11274 is a selective Met inhibitor with IC50 of 10 nM, but has no effects on PGDFRβ, EGFR or Tie2.

ENCOMPASS_PREFERRED
Kemisk navn eller materiale SU11274
Formel vægt 568.09
Opløselighedsinformation DMSO : ≥ 100 mg/mL (176.03 mM)
Procent renhed 98.19%
Fysisk form Solid
Farve Orange
Grad Research
Anbefalet opbevaring Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol) 568.09
CAS 658084-23-2
Synonym PKI-SU11274
Holdbarhed Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL O=S(C1=CC2=C(C=C1)NC(/C2=C/C3=C(C(C(N4CCN(CC4)C)=O)=C(N3)C)C)=O)(N(C)C5=CC=CC(Cl)=C5)=O
Renhedsgrad noter Research
Molekylær formel C28H30ClN5O4S
Til brug med (applikation) Cancer-Kinase/protease
11

TG101209, MedChemExpress

MedChemExpress TG101209 is a selective JAK2 inhibitor with IC50 of 6 nM, less potent to Flt3 and RET with IC50 of 25 nM and 17 nM, appr 30-fold selective for JAK2 than JAK3, and sensitive to JAK2V617F and MPLW515L/K mutations.

ENCOMPASS_PREFERRED
Kemisk navn eller materiale TG101209
Formel vægt 509.67
Opløselighedsinformation DMSO : ≥ 50 mg/mL (98.10 mM)
Procent renhed 98.81%
Fysisk form Solid
Farve Gray
Grad Research
Anbefalet opbevaring Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol) 509.67
CAS 936091-14-4
Holdbarhed Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL O=S(C1=CC=CC(NC2=NC(NC3=CC=C(C=C3)N4CCN(CC4)C)=NC=C2C)=C1)(NC(C)(C)C)=O
Renhedsgrad noter Research
Molekylær formel C26H35N7O2S
Til brug med (applikation) Cancer-Kinase/protease
12

Veralipride, MedChemExpress

MedChemExpress Veralipride is a D2 receptor antagonist. It is an alternative antidopaminergic treatment for menopausal symptoms.

ENCOMPASS_PREFERRED
Kemisk navn eller materiale Veralipride
Formel vægt 383.46
Opløselighedsinformation DMSO : ≥ 100 mg/mL (260.78 mM)
Procent renhed 99.57%
Fysisk form Solid
Farve White
Grad Research
Anbefalet opbevaring Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol) 383.46
CAS 66644-81-3
Synonym (±)-Veralipride LIR166
Holdbarhed Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL O=C(NCC1N(CC=C)CCC1)C2=CC(S(=O)(N)=O)=CC(OC)=C2OC
Renhedsgrad noter Research
Molekylær formel C17H25N3O5S
Til brug med (applikation) Neuroscience-Neurodegeneration
13

PF-06471553, MedChemExpress

MedChemExpress PF-06471553 is a potent, selective and orally available monoacylglycerol acyltransferase 3 (MGAT3) inhibitor, with an IC50 of 92 nM.

ENCOMPASS_PREFERRED
Kemisk navn eller materiale PF-06471553
Formel vægt 467.54
Opløselighedsinformation DMSO : ≥ 150 mg/mL (320.83 mM)
Procent renhed 98.18%
Fysisk form Solid
Farve White
Grad Research
Anbefalet opbevaring Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol) 467.54
CAS 1808094-07-6
Holdbarhed Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL O=S(C1=CC2=C(CN(C(CC3=CC=CC(OC)=C3)=O)C2)C=C1)(NC4=NN(C5CCC5)N=C4)=O
Renhedsgrad noter Research
Molekylær formel C23H25N5O4S
Til brug med (applikation) Metabolism-sugar/lipid metabolism
14

AZD2098, MedChemExpress

MedChemExpress AZD2098 is a potent and selective CC-chemokine receptor 4 (CCR4) inhibitor with pIC50s of 7.8, 8.0, 8.0 and 7.6 for human, rat, mouse and dog respectively, used for asthma research.

ENCOMPASS_PREFERRED
Kemisk navn eller materiale AZD2098
Formel vægt 334.18
Opløselighedsinformation DMSO : 100 mg/mL (299.24 mM; Need ultrasonic)
Procent renhed 99.86%
Fysisk form Solid
Farve White
Grad Research
Anbefalet opbevaring Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol) 334.18
CAS 566203-88-1
Holdbarhed Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL O=S(C1=CC=CC(Cl)=C1Cl)(NC2=NC=CN=C2OC)=O
Renhedsgrad noter Research
Molekylær formel C11H9Cl2N3O3S
Til brug med (applikation) COVID-19-immunoregulation
15

HMN-176, MedChemExpress

MedChemExpress HMN-176 is a stilbene derivative which inhibits mitosis, interfering with polo-like kinase-1 (plk1), without significant effect on tubulin polymerization.

ENCOMPASS_PREFERRED
Kemisk navn eller materiale HMN-176
Formel vægt 382.43
Opløselighedsinformation DMSO : ≥ 30 mg/mL (78.45 mM)
Procent renhed 98.54%
Fysisk form Solid
Farve Light Yellow
Grad Research
Anbefalet opbevaring Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol) 382.43
CAS 173529-10-7
Holdbarhed Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL O=S(C1=CC=C(OC)C=C1)(NC2=CC=CC=C2/C=C/C3=CC=N(C=C3)=O)=O
Renhedsgrad noter Research
Molekylær formel C20H18N2O4S
Til brug med (applikation) Cancer-Kinase/protease