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Pyrimidiner og derivater

Aromatiske organiske forbindelser, der består af en aromatisk seksleddet ring indeholdende to ikke-tilstødende nitrogenatomer og fire carbonatomer; omfatter forbindelser afledt af pyrimidiner.

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1 – 15 af 113 Resultater
1

PROTAC BET Degrader-1, MedChemExpress

MedChemExpress PROTAC BET Degrader-1 is a PROTAC connected by ligands for Cereblon and BET, decreasing BRD2, BRD3, and BRD4 protein levels at low concentration.

ENCOMPASS_PREFERRED
Kemisk navn eller materiale PROTAC BET Degrader-1
Formel vægt 871.9
Opløselighedsinformation DMSO : ≥ 50 mg/mL (57.35 mM)
Procent renhed 98.01%
Fysisk form Solid
Farve Yellow
Grad Research
Anbefalet opbevaring Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol) 871.9
CAS 2093386-22-0
Holdbarhed Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL CCN1C(NC2=C3C4=CC(OC)=C(C(C(C)=NO5)=C5C)C=C4NC3=NC(C(NCCCCNC(COC6=C(C(N7C(CCC8=O)C(N8)=O)=O)C(C7=O)=CC=C6)=O)=O)=N2)=CC(C9CC9)=N1
Renhedsgrad noter Research
Molekylær formel C44H45N11O9
Til brug med (applikation) Cancer-programmed cell death
2

AF64394, MedChemExpress

MedChemExpress AF64394 is a GPR3 inverse agonist, with a pIC50 of 7.3.

ENCOMPASS_PREFERRED
Kemisk navn eller materiale AF64394
Sundhedsfare 1 H302
Formel vægt 393.87
Opløselighedsinformation DMSO : ≥ 125 mg/mL (317.36 mM)
Procent renhed 98.02%
Fysisk form Solid
Farve White
Grad Research
Anbefalet opbevaring Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol) 393.87
CAS 1637300-25-4
Holdbarhed Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL ClC1=CC(OC(C)C)=C(CNC2=CC(C3=CC=CC=C3)=NC4=NC=NN42)C=C1
Renhedsgrad noter Research
Molekylær formel C21H20ClN5O
3

WAY-600, MedChemExpress

MedChemExpress WAY-600 is a potent, ATP-competitive, and selective mTOR inhibitor with an IC50 of 9 nM for recombinant mTOR enzyme. WAY-600 blocks mTOR complex 1/2 (mTORC1/2) assemble and activation.

ENCOMPASS_PREFERRED
Kemisk navn eller materiale WAY-600
Formel vægt 494.59
Opløselighedsinformation DMSO : 50 mg/mL (101.09 mM; Need ultrasonic)
Procent renhed 95.12%
Fysisk form Solid
Farve White
Grad Research
Anbefalet opbevaring Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol) 494.59
CAS 1062159-35-6
Holdbarhed Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL C1(C=CN2)=C2C=CC(C3=NC(N(C4CCN(CC5=CC=CN=C5)CC4)N=C6)=C6C(N7CCOCC7)=N3)=C1
Renhedsgrad noter Research
Molekylær formel C28H30N8O
Til brug med (applikation) Cancer-Kinase/protease
4

PRT-060318, MedChemExpress

MedChemExpress PRT-060318 (PRT318) is a novel selective inhibitor of the tyrosine kinase Syk with an IC50 of 4 nM.

ENCOMPASS_PREFERRED
Kemisk navn eller materiale PRT-060318
Formel vægt 340.42
Opløselighedsinformation H2O : 5.6 mg/mL (16.45 mM; Need ultrasonic and warming)
Procent renhed 99.04%
Fysisk form Solid
Farve Earth Yellow
Grad Research
Anbefalet opbevaring Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol) 340.42
CAS 1194961-19-7
Synonym PRT318
Holdbarhed Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL O=C(C1=CN=C(N[C@H]2[C@@H](N)CCCC2)N=C1NC3=CC=CC(C)=C3)N
Renhedsgrad noter Research
Molekylær formel C18H24N6O
Til brug med (applikation) Cancer-Kinase/protease
5

EED226, MedChemExpress

MedChemExpress EED226 is a polycomb repressive complex 2 (PRC2) inhibitor, which binds to the K27me3-pocket on embryonic ectoderm development (EED) and shows strong antitumor activity in xenograft mice model. EED226 is a potent, selective, and orally bioavailable EED inhibitor. EED226 inhibits PRC2 with an IC50 of 23.4 nM when the H3K27me0 peptide is used as a substrate in the in vitro enzymatic assays.

ENCOMPASS_PREFERRED
Kemisk navn eller materiale EED226
Formel vægt 369.4
Opløselighedsinformation DMSO : ≥ 29 mg/mL (78.51 mM)
Procent renhed 98.61%
Fysisk form Solid
Farve Off-White
Grad Research
Anbefalet opbevaring Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol) 369.4
CAS 2083627-02-3
Holdbarhed Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL O=S(C1=CC=C(C2=CN=C(NCC3=CC=CO3)N4C2=NN=C4)C=C1)(C)=O
Renhedsgrad noter Research
Molekylær formel C17H15N5O3S
Til brug med (applikation) Cancer-programmed cell death
6

GSK2334470, MedChemExpress

MedChemExpress GSK2334470 is a highly specific and potent inhibitor of PDK1 with an IC50 of 10 nM.

ENCOMPASS_PREFERRED
Kemisk navn eller materiale GSK2334470
Sundhedsfare 1 H302
Formel vægt 462.59
Opløselighedsinformation DMSO : ≥ 50 mg/mL (108.09 mM)
Procent renhed 95.73%
Fysisk form Solid
Farve Light Yellow
Grad Research
Anbefalet opbevaring Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol) 462.59
CAS 1227911-45-6
Holdbarhed Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL O=C([C@@H]1CN(C2=NC(NC)=NC(C3=CC4=C(C=C3)C(N)=NN4)=C2)[C@H](C)CC1)NC5CCCCC5
Renhedsgrad noter Research
Molekylær formel C25H34N8O
Til brug med (applikation) Cancer-Kinase/protease
7

AZ20, MedChemExpress

MedChemExpress AZ20 is a potent and selective inhibitor of ATR with an IC50 of 5 nM, and has 8-fold selectivity against mTOR (IC50=38 nM).

ENCOMPASS_PREFERRED
Kemisk navn eller materiale AZ20
Formel vægt 412.51
Opløselighedsinformation DMSO : ≥ 100 mg/mL (242.42 mM)
Procent renhed 98.92%
Fysisk form Solid
Farve Off-White
Grad Research
Anbefalet opbevaring Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol) 412.51
CAS 1233339-22-4
Holdbarhed Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL O=S(C1(C2=CC(N3[C@H](C)COCC3)=NC(C4=CC=CC5=C4C=CN5)=N2)CC1)(C)=O
Renhedsgrad noter Research
Molekylær formel C21H24N4O3S
Til brug med (applikation) Cancer-Kinase/protease
8

HJB97, MedChemExpress

MedChemExpress HJB97 is a high-affinity BET inhibitor with Kis of 0.9 nM (BRD2 BD1), 0.27 nM (BRD2 BD2), 0.18 nM (BRD3 BD1), 0.21 nM (BRD3 BD2), 0.5 nM (BRD4 BD1), 1.0 nM (BRD4 BD2), respectively. HJB97 is employed for the design of potential PROTAC BET degrader and has antitumor activity.

ENCOMPASS_PREFERRED
Kemisk navn eller materiale HJB97
Formel vægt 500.55
Opløselighedsinformation DMSO : 30 mg/mL (59.93 mM; Need ultrasonic)
Procent renhed 98.24%
Fysisk form Solid
Farve Yellow
Grad Research
Anbefalet opbevaring Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol) 500.55
CAS 2093391-24-1
Holdbarhed Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL O=C(C1=NC(NC2=CC(C3CC3)=NN2CC)=C4C(NC5=C4C=C(OC)C(C6=C(C)ON=C6C)=C5)=N1)NC
Renhedsgrad noter Research
Molekylær formel C26H28N8O3
Til brug med (applikation) Cancer-programmed cell death
9

PF-06928215, MedChemExpress

MedChemExpress PF-06928215 is a cGAS (cyclic GMP-AMP Synthase) inhibitor with an IC50 of 4.9 μμ. PF-06928215 has a high binding affinity of 0.2 μM (Kd).

ENCOMPASS_PREFERRED
10

VUF10460, MedChemExpress

MedChemExpress VUF10460 is a non-imidazole histamine H4 receptor agonist; binds to rat H4 receptor with a pKi of 7.46.

ENCOMPASS_PREFERRED
Kemisk navn eller materiale VUF10460
Formel vægt 269.34
Opløselighedsinformation DMSO : 50 mg/mL (185.64 mM; Need ultrasonic)
Procent renhed 98.0%
Fysisk form Solid
Farve Light Yellow
Grad Research
Anbefalet opbevaring Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol) 269.34
CAS 1028327-66-3
Holdbarhed Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL NC1=NC(C2=CC=CC=C2)=CC(N3CCN(C)CC3)=N1
Renhedsgrad noter Research
Molekylær formel C15H19N5
Til brug med (applikation) COVID-19-immunoregulation
11

ML347, MedChemExpress

MedChemExpress ML347 (LDN193719) is a highly selective ALK1/ALK2 inhibitor. ML347 has IC50 values of 46 and 32 nM against ALK1 and ALK2, respectively, >300-fold selective over ALK3. ML347 block the phosphorylation of Smad1/5 by TGF-β1.

ENCOMPASS_PREFERRED
Kemisk navn eller materiale ML347
Formel vægt 352.39
Opløselighedsinformation DMSO : 10 mg/mL (28.38 mM; Need ultrasonic)
Procent renhed 99.85%
Fysisk form Solid
Farve Yellow
Grad Research
Anbefalet opbevaring Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol) 352.39
CAS 1062368-49-3
Synonym LDN 193719
Holdbarhed Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL COC1=CC=C(C2=CN3C(N=C2)=C(C4=C5C=CC=NC5=CC=C4)C=N3)C=C1
Renhedsgrad noter Research
Molekylær formel C22H16N4O
Til brug med (applikation) Cancer-Kinase/protease
12

G-749, MedChemExpress

MedChemExpress G-749 is a potent, oral active and ATP competitive FLT3 inhibitor, with IC50s of 0.4 nM and 0.6 nM for FLT3 wild type and FLT3-D835Y, respectively. G-749 can be used for the research of drug resistance for acute myeloid leukemia (AML).

ENCOMPASS_PREFERRED
Kemisk navn eller materiale G-749
Formel vægt 521.41
Opløselighedsinformation DMSO : 25 mg/mL (47.95 mM; Need ultrasonic)
Procent renhed 98.0%
Fysisk form Solid
Farve Off-White
Grad Research
Anbefalet opbevaring Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol) 521.41
CAS 1457983-28-6
Holdbarhed Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL O=C1C2=C(N=C(NC3CCN(C)CC3)N=C2NC4=CC=C(OC5=CC=CC=C5)C=C4)C(Br)=CN1
Renhedsgrad noter Research
Molekylær formel C25H25BrN6O2
Til brug med (applikation) Cancer-Kinase/protease
13

BMS-833923, MedChemExpress

MedChemExpress BMS-833923 (XL-139) is an orally bioavailable small-molecule inhibitor of Smoothened with potential antineoplastic activity; inhibits BODIPY cyclopamine binding to SMO in a dose-dependent manner with an IC50 of 21 nM.

ENCOMPASS_PREFERRED
Kemisk navn eller materiale BMS-833923
Sundhedsfare 1 H302
Formel vægt 473.57
Opløselighedsinformation DMSO : 50 mg/mL (105.58 mM; Need ultrasonic)
Procent renhed 98.21%
Fysisk form Solid
Farve Yellow
Grad Research
Anbefalet opbevaring Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol) 473.57
CAS 1059734-66-5
Synonym XL-139
Holdbarhed Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL O=C(NC1=CC(CNC)=CC=C1C)C2=CC=C(NC3=NC(C4=CC=CC=C4)=C5C=CC=CC5=N3)C=C2
Renhedsgrad noter Research
Molekylær formel C30H27N5O
Til brug med (applikation) Cancer-programmed cell death
14

LDC000067, MedChemExpress

MedChemExpress LDC000067 is a highly specific CDK9 inhibitor with an IC50 value of 44±10 nM in vitro.

ENCOMPASS_PREFERRED
Kemisk navn eller materiale LDC000067
Formel vægt 370.43
Opløselighedsinformation DMSO : ≥ 47 mg/mL (126.88 mM)
Procent renhed 98.58%
Fysisk form Solid
Farve Off-White
Grad Research
Anbefalet opbevaring Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol) 370.43
CAS 1073485-20-7
Synonym LDC067
Holdbarhed Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL O=S(CC1=CC=CC(NC2=NC=NC(C3=CC=CC=C3OC)=C2)=C1)(N)=O
Renhedsgrad noter Research
Molekylær formel C18H18N4O3S
Til brug med (applikation) Cancer-Kinase/protease
15

MK-8617, MedChemExpress

MedChemExpress MK-8617 is an orally active pan-inhibitor of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) with an IC50 of 1 nM for PHD2.

ENCOMPASS_PREFERRED
Kemisk navn eller materiale MK-8617
Formel vægt 443.45
Opløselighedsinformation DMSO : 6 mg/mL (13.53 mM; Need ultrasonic)
Procent renhed 98.02%
Fysisk form Solid
Farve White
Grad Research
Anbefalet opbevaring Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol) 443.45
CAS 1187990-87-9
Holdbarhed Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL O=C(C1=CN=C(C2=NN=CC=C2)N=C1O)NC(C3=CC=C(OC)C=C3)C4=CC=C(OC)C=C4
Renhedsgrad noter Research
Molekylær formel C24H21N5O4
Til brug med (applikation) COVID-19-immunoregulation