Tetrahydroisoquinoliner

Organiske heterocykliske forbindelser, der består af en isoquinolinring uden dobbeltbindinger; indeholder en benzenring fusioneret til en seksleddet ring med et nitrogenatom og fem carbonatomer.

Hydrastine, MedChemExpress

MedChemExpress Hydrastine is a natural alkaloid which is present in Hydrastis canadensis and other plants of the ranunculaceae family.

Pris og tilgængelighed
Tekniske data

Kemisk navn eller materiale	Hydrastine
Formel vægt	383.39
Opløselighedsinformation	DMSO : 100 mg/mL (260.83 mM; Need ultrasonic)
Procent renhed	99.0%
Fysisk form	Solid
Farve	Light Yellow
Grad	Research
Anbefalet opbevaring	Powder -20°C 3 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol)	383.39
CAS	118-08-1
Synonym	(-)-β-Hydrastine (1R,9S)-β-Hydrastine
Holdbarhed	Powder -20°C 3 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL	O=C1O[C@H]([C@@H]2N(C)CCC3=C2C=C(OCO4)C4=C3)C5=C1C(OC)=C(OC)C=C5
Renhedsgrad noter	Research
Molekylær formel	C₂₁H₂₁NO₆

(-)-Isocorypalmine, MedChemExpress

MedChemExpress (-)-Isocorypalmine (Tetrahydrocolumbamine), isolated from the crude base fraction of Corydalis chaerophylla, is a dopamine receptor ligand. Recombinant CYP719A21 displays strict substrate specificity and high affinity (Km=4.63 ± 0.71 μM) for (-)-Isocorypalmine.

Pris og tilgængelighed

Norisoboldine, MedChemExpress

MedChemExpress Norisoboldine is an orally active natural aryl hydrocarbon receptor (AhR) agonist. Norisoboldine, as a major isoquinoline alkaloid present in Radix Linderae, can be used for the research of Rheumatoid arthritis and Ulcerative colitis.

Pris og tilgængelighed
Tekniske data

Kemisk navn eller materiale	Norisoboldine
Formel vægt	313.35
Opløselighedsinformation	DMSO : ≥ 62.5 mg/mL (199.46 mM)
Procent renhed	99.44%
Fysisk form	Solid
Farve	Brown
Grad	Research
Anbefalet opbevaring	4°C, protect from light∣In solvent : -80°C, 6 months∣-20°C, 1 month (protect from light)
Molekylvægt (g/mol)	313.35
CAS	23599-69-1
Synonym	(+)-Laurelliptine
Holdbarhed	4°C, protect from light∣In solvent : -80°C, 6 months∣-20°C, 1 month (protect from light)
SMIL	OC1=C(OC)C=C2CCN[C@@]3([H])CC4=CC(O)=C(OC)C=C4C1=C23
Renhedsgrad noter	Research
Molekylær formel	C₁₈H₁₉NO₄
Til brug med (applikation)	COVID-19-immunoregulation

CIQ, MedChemExpress

MedChemExpress CIQ is a subunit-selective potentiator of NMDA receptors containing the NR2C or NR2D subunit.

Pris og tilgængelighed
Tekniske data

Kemisk navn eller materiale	CIQ
Formel vægt	467.94
Opløselighedsinformation	DMSO : ≥ 50 mg/mL (106.85 mM)
Procent renhed	98.07%
Fysisk form	Solid
Farve	White
Grad	Research
Anbefalet opbevaring	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol)	467.94
CAS	486427-17-2
Holdbarhed	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL	O=C(C1=CC=CC(Cl)=C1)N2C(COC3=CC=C(OC)C=C3)C4=C(C=C(OC)C(OC)=C4)CC2
Renhedsgrad noter	Research
Molekylær formel	C₂₆H₂₆ClNO₅
Til brug med (applikation)	Neuroscience-Neurodegeneration

YS-49 monohydrate, MedChemExpress

MedChemExpress YS-49 (monohydrate) is a PI3K/Akt (a downstream target of RhoA) activator, to reduce RhoA/PTEN activation in the 3-methylcholanthrene-treated cells. YS-49 inhibits angiotensin II (Ang II)-stimulated proliferation of VSMCs via induction of heme oxygenase (HO)-1. YS-49 is also an isoquinoline compound alkaloid, has a strong positive inotropic action through activation of cardiac β-adrenoceptors.

Pris og tilgængelighed
Tekniske data

Kemisk navn eller materiale	YS-49 monohydrate
Anbefalet opbevaring	4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Molekylvægt (g/mol)	404.3
Formel vægt	404.3
Holdbarhed	4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Procent renhed	99.56%
SMIL	OC1=CC2=C(C(CC3=C4C=CC=CC4=CC=C3)NCC2)C=C1O.O.Br
Renhedsgrad noter	Research
Fysisk form	Solid
Molekylær formel	C₂₀H₂₂BrNO₃
Farve	Gray
Til brug med (applikation)	Neuroscience-Neuromodulation
Grad	Research

SR10067, MedChemExpress

MedChemExpress SR10067 is a potent, selective and brain penetrant Rev-Erbα/β agonist, with IC50 values are 160 and 170 nM for Rev-Erbβ and Rev-Erbα, respectively. SR10067 has anxiolytic activity.

Pris og tilgængelighed

Lurbinectedin, MedChemExpress

MedChemExpress Lurbinectedin (PM01183) is a DNA minor groove covalent binder with potent anti-tumour activity; inhibits RMG1 and RMG2 cell growth with IC50 values of 1.25 and 1.16 nM, respectively.

Pris og tilgængelighed
Tekniske data

Kemisk navn eller materiale	Lurbinectedin
Formel vægt	784.87
Opløselighedsinformation	DMSO : 20 mg/mL (25.48 mM; Need ultrasonic)
Procent renhed	97.13%
Fysisk form	Solid
Farve	Light Yellow
Grad	Research
Anbefalet opbevaring	Powder -20°C 3 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol)	784.87
CAS	497871-47-3
Synonym	PM01183
Holdbarhed	Powder -20°C 3 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL	O[C@@H]([C@@](CC1=CC(C)=C2OC)([H])N(C)[C@]3([H])C1=C2O)N([C@](COC4=O)([H])C5=C(OCO6)C6=C7C)[C@@]3([H])[C@@](SC[C@@]4(NCC8)C9=C8C%10=CC(OC)=CC=C%10N9)([H])C5=C7OC(C)=O
Renhedsgrad noter	Research
Molekylær formel	C₄₁H₄₄N₄O₁₀S
Til brug med (applikation)	Cancer-programmed cell death

Salsolidine, MedChemExpress

MedChemExpress Salsolidine is a tetrahydroisoquinoline alkaloid, acts as a stereoselective competitive MAO A inhibitor.

Pris og tilgængelighed
Tekniske data

Kemisk navn eller materiale	Salsolidine
Sundhedsfare 1	H302∣H315∣H319∣H335
Formel vægt	207.27
Opløselighedsinformation	DMSO : 50 mg/mL (241.23 mM; Need ultrasonic)
Procent renhed	95.0%
Fysisk form	Solid
Farve	Yellow
Grad	Research
Anbefalet opbevaring	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol)	207.27
CAS	5784-74-7
Holdbarhed	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL	CC1NCCC2=C1C=C(OC)C(OC)=C2
Renhedsgrad noter	Research
Molekylær formel	C₁₂H₁₇NO₂
Til brug med (applikation)	Neuroscience-Neuromodulation

Nuciferine, MedChemExpress

MedChemExpress Nuciferine is an antagonist at 5-HT2A (IC50=478 nM), 5-HT2C (IC50=131 nM), and 5-HT2B (IC50=1 μM), an inverse agonist at 5-HT7 (IC50=150 nM), a partial agonist at D2 (EC50=64 nM), D5 (EC50=2.6 μM) and 5-HT6 (EC50=700 nM), an agonist at 5-HT1A (EC50=3.2 μM) and D4 (EC50=2 μM) receptor.

Pris og tilgængelighed
Tekniske data

Kemisk navn eller materiale	Nuciferine
Sundhedsfare 1	H302∣H315∣H319∣H335
Formel vægt	295.38
Opløselighedsinformation	DMSO : 11.11 mg/mL (37.61 mM; Need ultrasonic)
Procent renhed	99.66%
Fysisk form	Solid
Farve	Off-White
Grad	Research
Anbefalet opbevaring	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol)	295.38
CAS	475-83-2
Holdbarhed	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL	CN1CCC2=CC(OC)=C(OC)C3=C2[C@@]1([H])CC4=CC=CC=C34
Renhedsgrad noter	Research
Molekylær formel	C₁₉H₂₁NO₂
Til brug med (applikation)	Neuroscience-Neuromodulation

Nomifensine, MedChemExpress

MedChemExpress Nomifensine is a norepinephrine-dopamine reuptake inhibitor, increases the amount of synaptic norepinephrine and dopamine available to receptors by blocking the dopamine and norepinephrine reuptake transporters.

Pris og tilgængelighed
Tekniske data

Kemisk navn eller materiale	Nomifensine
Sundhedsfare 1	H302
Formel vægt	238.33
Opløselighedsinformation	DMSO : ≥ 100 mg/mL (419.59 mM)
Procent renhed	95.0%
Fysisk form	Solid
Farve	Light Yellow
Grad	Research
Anbefalet opbevaring	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol)	238.33
CAS	24526-64-5
Synonym	(±)-Nomifensin
Holdbarhed	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL	NC1=CC=CC2=C1CN(C)CC2C3=CC=CC=C3
Renhedsgrad noter	Research
Molekylær formel	C₁₆H₁₈N₂
Til brug med (applikation)	Neuroscience-Neuromodulation

L-Praziquanamine, MedChemExpress

MedChemExpress L-Praziquanamine is a natural product.

Pris og tilgængelighed
Tekniske data

Kemisk navn eller materiale	L-Praziquanamine
Formel vægt	202.25
Opløselighedsinformation	DMSO : 100 mg/mL (494.44 mM; Need ultrasonic)
Fysisk form	Solid
Farve	Off-White
Grad	Research
Anbefalet opbevaring	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol)	202.25
CAS	99746-73-3
Synonym	(+)-Praziquanamine
Holdbarhed	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL	O=C1CNC[C@@]2([H])N1CCC3=C2C=CC=C3
Renhedsgrad noter	Research
Molekylær formel	C₁₂H₁₄N₂O

Tetrahydroberberine, MedChemExpress

MedChemExpress Tetrahydroberberine is an isoquinoline alkaloid isolated from corydalis tuber; has micromolar affinity for dopamine D(2) (pK(i) = 6.08) and 5-HT(1A) (pK(i) = 5.38) receptors but moderate to no affinity for other relevant serotonin receptors (5-HT(1B), 5-HT(1D), 5-HT(3), and 5-HT(4); pK(i) < 5.00).

Pris og tilgængelighed
Tekniske data

Kemisk navn eller materiale	Tetrahydroberberine
Formel vægt	339.39
Opløselighedsinformation	DMSO : 25 mg/mL (73.66 mM; Need ultrasonic)
Procent renhed	99.65%
Fysisk form	Solid
Farve	Yellow
Grad	Research
Anbefalet opbevaring	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol)	339.39
CAS	522-97-4
Synonym	Canadine
Holdbarhed	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL	COC1=CC=C(CC23)C(CN2CCC(C3=C4)=CC5=C4OCO5)=C1OC
Renhedsgrad noter	Research
Molekylær formel	C₂₀H₂₁NO₄
Til brug med (applikation)	Neuroscience-Neuromodulation

Tetrabenazine Racemate, MedChemExpress

MedChemExpress Tetrabenazine Racemate (Ro 1-9569 Racemate) is a selective and reversible inhibitor of vesicular monoamine transporter-2 (VMAT-2).

Pris og tilgængelighed
Tekniske data

Kemisk navn eller materiale	Tetrabenazine Racemate
Formel vægt	317.42
Opløselighedsinformation	DMSO : 50 mg/mL (157.52 mM; Need ultrasonic)
Procent renhed	98.0%
Fysisk form	Solid
Farve	Light Yellow
Grad	Research
Anbefalet opbevaring	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol)	317.42
CAS	718635-93-9
Synonym	Ro 1-9569 Racemate
Holdbarhed	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL	O=C1C(CC(C)C)CN2CCC3=CC(OC)=C(OC)C=C3C2C1
Renhedsgrad noter	Research
Molekylær formel	C₁₉H₂₇NO₃
Til brug med (applikation)	Neuroscience-Neuromodulation

Tetrahydropalmatine, MedChemExpress

MedChemExpress Tetrahydropalmatine possesses analgesic effects. Tetrahydropalmatine acts through inhibition of amygdaloid release of dopamine to inhibit an epileptic attack in rats.

Pris og tilgængelighed
Tekniske data

Kemisk navn eller materiale	Tetrahydropalmatine
Formel vægt	355.43
Opløselighedsinformation	DMSO : 6.67 mg/mL (18.77 mM; Need ultrasonic)
Procent renhed	99.07%
Fysisk form	Solid
Farve	Off-White
Grad	Research
Anbefalet opbevaring	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol)	355.43
CAS	2934-97-6
Synonym	DL-Tetrahydropalmatine
Holdbarhed	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL	COC1=CC=C2C(CN3CCC4=CC(OC)=C(OC)C=C4C3C2)=C1OC
Renhedsgrad noter	Research
Molekylær formel	C₂₁H₂₅NO₄
Til brug med (applikation)	Neuroscience-Neurodegeneration

GSK591, MedChemExpress

MedChemExpress GSK591 (EPZ015866) is a potent and selective inhibitor of protein methyltransferase 5 (PRMT5) with an IC50 of 4 nM.

Pris og tilgængelighed
Tekniske data

Kemisk navn eller materiale	GSK591
Formel vægt	380.48
Opløselighedsinformation	DMSO : ≥ 135 mg/mL (354.81 mM)
Procent renhed	98.86%
Fysisk form	Solid
Farve	White
Grad	Research
Anbefalet opbevaring	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol)	380.48
CAS	1616391-87-7
Synonym	EPZ015866 GSK3203591
Holdbarhed	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL	O=C(C1=CC(NC2CCC2)=NC=C1)NC[C@H](O)CN3CC4=C(C=CC=C4)CC3
Renhedsgrad noter	Research
Molekylær formel	C₂₂H₂₈N₄O₂
Til brug med (applikation)	Cancer-programmed cell death

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Tetrahydroisoquinoliner

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