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Aromatiske organiske heterocykliske forbindelser, der består af en femleddet ring med fire carbonatomer og et nitrogenatom, der danner en aminfunktionel gruppe.

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1 – 15 af 184 Resultater
1

PCI-34051, MedChemExpress

MedChemExpress PCI-34051 is a potent and selective HDAC8 inhibitor with IC50 of 10 nM, with >200-fold selectivity over the other HDAC isoforms.

ENCOMPASS_PREFERRED
Kemisk navn eller materiale PCI-34051
Formel vægt 296.32
Opløselighedsinformation DMSO : ≥ 30 mg/mL (101.24 mM)
Procent renhed 97.28%
Fysisk form Solid
Farve Off-White
Grad Research
Anbefalet opbevaring Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol) 296.32
CAS 950762-95-5
Holdbarhed Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL COC(C=C1)=CC=C1CN2C3=CC(C(NO)=O)=CC=C3C=C2
Renhedsgrad noter Research
Molekylær formel C17H16N2O3
Til brug med (applikation) Cancer-programmed cell death
2

Vinburnine, MedChemExpress

MedChemExpress Vincamone is a vinca alkaloid and a metabolite of vincamine, is a vasodilator.

ENCOMPASS_PREFERRED
3

SB269652, MedChemExpress

MedChemExpress SB269652 is the first drug-like allosteric modulator of the dopamine D2 receptor (D2R); a new chemical probe that can differentiate D2R monomers from dimers or oligomers depending on the observed pharmacology.

ENCOMPASS_PREFERRED
4

Apyramide, MedChemExpress

MedChemExpress Apyramide is an anti-inflammatory agent (NSAID) and behaves as a prodrug of indomethacin (HY-14397). Indomethacin is a potent, blood-brain permeable and nonselective inhibitor of COX1 and COX2.

ENCOMPASS_PREFERRED
Kemisk navn eller materiale Apyramide
Formel vægt 490.93
Procent renhed 99.06%
Fysisk form Solid
Farve White
Grad Research
Anbefalet opbevaring Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol) 490.93
CAS 68483-33-0
Holdbarhed Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL O=C(OC1=CC=C(NC(C)=O)C=C1)CC2=C(C)N(C(C3=CC=C(Cl)C=C3)=O)C4=C2C=C(OC)C=C4
Renhedsgrad noter Research
Molekylær formel C27H23ClN2O5
Til brug med (applikation) COVID-19-immunoregulation
5

Oncrasin-1, MedChemExpress

MedChemExpress Oncrasin-1 is a potent and effective anticancer inhibitor that kills various human lung cancer cells with K-Ras mutations at low or submicromolar concentrations; also led to abnormal aggregation of PKCι in nucleus of sensitive cells but not in resistant cells.

ENCOMPASS_PREFERRED
Kemisk navn eller materiale Oncrasin-1
Formel vægt 269.73
Opløselighedsinformation DMSO : ≥ 43 mg/mL (159.42 mM)
Procent renhed 98.28%
Fysisk form Solid
Farve Earth Yellow
Grad Research
Anbefalet opbevaring Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol) 269.73
CAS 75629-57-1
Holdbarhed Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL O=CC1=CN(CC(C=C2)=CC=C2Cl)C3=CC=CC=C31
Renhedsgrad noter Research
Molekylær formel C16H12ClNO
Til brug med (applikation) Cancer-Kinase/protease
6

5-Iodotubercidin, MedChemExpress

MedChemExpress 5-Iodotubercidin (NSC 113939), an ATP mimetic, is a potent adenosine kinase inhibitor with an IC50 of 26 nM. 5-Iodotubercidin (NSC 113939) initiates glycogen synthesis in isolated hepatocytes by causing inactivation of phosphorylase and activation of glycogen synthase. 5-Iodotubercidin (NSC 113939) also inhibits CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2, PKC and Haspin.

ENCOMPASS_PREFERRED
Kemisk navn eller materiale 5-Iodotubercidin
Sundhedsfare 1 H315∣H319∣H335
Formel vægt 392.15
Opløselighedsinformation DMSO : ≥ 49 mg/mL (124.95 mM)
Procent renhed 95.0%
Fysisk form Solid
Farve Earth Yellow
Grad Research
Anbefalet opbevaring Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol) 392.15
CAS 24386-93-4
Synonym NSC 113939 5-ITu
Holdbarhed Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL NC1=C2C(N([C@H]3[C@H](O)[C@H](O)[C@@H](CO)O3)C=C2I)=NC=N1
Renhedsgrad noter Research
Molekylær formel C11H13IN4O4
Til brug med (applikation) Cancer-Kinase/protease
7

Metergoline, MedChemExpress

MedChemExpress Metergoline is a serotonin (5-HT) receptor and dopamine receptors antagonist, with pKis of 8.64, 8.75 and 8.75 for 5-HT2A, 5-HT2B and 5-HT2C, respectively. Metergoline is a high-affinity ligand for the h5-HT7 receptor, with a Ki of 16 nM. Metergoline is also a reversible neural Na+ channels inhibitor. Metergoline is commonly used for the research of seasonal affective disorder, prolactin hormone regulation.

ENCOMPASS_PREFERRED
Kemisk navn eller materiale Metergoline
Sundhedsfare 1 H302∣H312∣H332
Formel vægt 403.52
Opløselighedsinformation DMSO : 125 mg/mL (309.77 mM; Need ultrasonic)
Procent renhed 98.62%
Fysisk form Solid
Farve White
Grad Research
Anbefalet opbevaring Powder -20°C 3 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol) 403.52
CAS 17692-51-2
Holdbarhed Powder -20°C 3 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL O=C(OCC1=CC=CC=C1)NC[C@H](C[C@@]23[H])CN(C)[C@]2([H])CC4=CN(C)C5=CC=CC3=C54
Renhedsgrad noter Research
Molekylær formel C25H29N3O2
Til brug med (applikation) Neuroscience-Neuromodulation
8

(R)-Ketorolac, MedChemExpress

MedChemExpress (R)-Ketorolac is the R-enantiomer of Ketorolac, shows potent analgesic activity, reduces ulcerogenic potential. (R)-Ketorolac is inactive on COX.

ENCOMPASS_PREFERRED
Kemisk navn eller materiale (R)-Ketorolac
Sundhedsfare 1 H315∣H319∣H335
Formel vægt 255.27
Opløselighedsinformation DMSO : ≥ 100 mg/mL (391.74 mM)
Procent renhed 98.38%
Fysisk form Solid
Farve Off-White
Grad Research
Anbefalet opbevaring Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol) 255.27
CAS 66635-93-6
Synonym (+)-Ketorolac
Holdbarhed Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL O=C(C1=CC=CC=C1)C2=CC=C3N2CC[C@H]3C(O)=O
Renhedsgrad noter Research
Molekylær formel C15H13NO3
Til brug med (applikation) Neuroscience-Neuromodulation
9

YM-90709, MedChemExpress

MedChemExpress YM-90709 is a novel IL-5 inhibitor which selectively blocks the binding of IL-5 to the IL-5 receptor (IL-5R).YM-90709 potently inhibits the binding of [125I]-IL-5 to IL-5R on human peripheral eosinophils and eosinophilic HL-60 clone 15 cells with IC50 values of 1.0 and 0.57 μM.

ENCOMPASS_PREFERRED
Kemisk navn eller materiale YM-90709
Formel vægt 359.42
Opløselighedsinformation DMSO : 62.5 mg/mL (173.89 mM; Need ultrasonic)
Procent renhed 99.52%
Fysisk form Solid
Farve Orange
Grad Research
Anbefalet opbevaring Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol) 359.42
CAS 163769-88-8
Holdbarhed Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL CC(CC1=CC(OC)=C(OC)C=C12)(C)N3C2=CC4=NC5=CC=CC=C5N=C43
Renhedsgrad noter Research
Molekylær formel C22H21N3O2
Til brug med (applikation) COVID-19-immunoregulation
10

(S)-Ketorolac, MedChemExpress

MedChemExpress (S)-Ketorolac is a nonsteroidal anti-inflammatory agent. (S)-ketorolac exhibits potent COX1 and COX2 enzyme inhibition.

ENCOMPASS_PREFERRED
Kemisk navn eller materiale (S)-Ketorolac
Formel vægt 255.27
Opløselighedsinformation DMSO : 200 mg/mL (783.48 mM; Need ultrasonic)
Procent renhed 99.62%
Fysisk form Solid
Farve Off-White
Grad Research
Anbefalet opbevaring Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol) 255.27
CAS 66635-92-5
Synonym (-)-Ketorolac
Holdbarhed Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL O=C(C1=CC=CC=C1)C2=CC=C3N2CC[C@@H]3C(O)=O
Renhedsgrad noter Research
Molekylær formel C15H13NO3
Til brug med (applikation) Neuroscience-Neuromodulation
11

AM679, MedChemExpress

MedChemExpress AM679 is a potent, selective 5-lipoxygenase-activating protein (FLAP) inhibitor with an IC50 of 2 nM in a human FLAP membrane binding assay. AM679 markedly reduces the respiratory syncytial virus-driven ocular pathology as well as the synthesis of cysteinyl leukotrienes (CysLTs) in the eye.

ENCOMPASS_PREFERRED
Kemisk navn eller materiale AM679
Formel vægt 692.87
Opløselighedsinformation DMSO : ≥ 100 mg/mL (144.33 mM)
Procent renhed 99.6%
Fysisk form Solid
Farve pale pink
Grad Research
Anbefalet opbevaring Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol) 692.87
CAS 1206880-66-1
Holdbarhed Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL O=C(C)N1C2=CC=CC=C2C[C@H]1COC3=CC=C(N(CC4=CC=C(C5=NC=C(OC)C=N5)C=C4)C(CC(C)(C(O)=O)C)=C6SC(C)(C)C)C6=C3
Renhedsgrad noter Research
Molekylær formel C40H44N4O5S
Til brug med (applikation) COVID-19-immunoregulation
12

GSK376501A, MedChemExpress

MedChemExpress GSK376501A is a selective peroxisome proliferator-activated receptor gamma (PPARγ) modulator for the treatment of type 2 diabetes mellitus.

ENCOMPASS_PREFERRED
13

VU0661013, MedChemExpress

MedChemExpress VU661013 is a potent and selective MCL-1 inhibitor.

ENCOMPASS_PREFERRED
Kemisk navn eller materiale VU0661013
Formel vægt 712.66
Opløselighedsinformation DMSO : ≥ 125 mg/mL (175.40 mM)
Procent renhed 98.52%
Fysisk form Solid
Farve Light Yellow
Grad Research
Anbefalet opbevaring Powder -20°C 3 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol) 712.66
CAS 2131184-57-9
Holdbarhed Powder -20°C 3 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL ClC1=CC=C(C(CCCOC2=CC(C)=C(Cl)C(C)=C2)=C3N4[C@H](C)CN(C5=CN(C)C6=C5C=C(C(O)=O)C=C6)C3=O)C4=C1C7=C(C)N(C)N=C7C
Renhedsgrad noter Research
Molekylær formel C39H39Cl2N5O4
Til brug med (applikation) Cancer-programmed cell death
14

JNJ-7777120, MedChemExpress

MedChemExpress JNJ-7777120 is a selective H4R antagonist with Ki of 4 ±1 nM, exhibits >1000-fold selectivity over the other histamin receptors.

ENCOMPASS_PREFERRED
Kemisk navn eller materiale JNJ-7777120
Sundhedsfare 1 H315∣H319∣H335
Formel vægt 277.75
Opløselighedsinformation DMSO : ≥ 50 mg/mL (180.02 mM)
Procent renhed 98.0%
Fysisk form Solid
Farve White
Grad Research
Anbefalet opbevaring Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol) 277.75
CAS 459168-41-3
Holdbarhed Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL O=C(C(N1)=CC2=C1C=CC(Cl)=C2)N3CCN(C)CC3
Renhedsgrad noter Research
Molekylær formel C14H16ClN3O
Til brug med (applikation) COVID-19-immunoregulation
15

CAY10650, MedChemExpress

MedChemExpress CAY10650 is a highly potent cytosolic phospholipase A2α (cPLA2α) inhibitor with an IC50 value of 12 nM. CAY10650 suppresses lipid droplets formation and PGE2 secretion.

ENCOMPASS_PREFERRED
Kemisk navn eller materiale CAY10650
Formel vægt 471.5
Opløselighedsinformation DMSO : ≥ 43 mg/mL (91.20 mM)
Procent renhed 98.0%
Fysisk form Solid
Farve Off-White
Grad Research
Anbefalet opbevaring Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol) 471.5
CAS 1233706-88-1
Holdbarhed Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL O=C(CN1C(C=CC(C(O)=O)=C2)=C2C(C(C(C)C)=O)=C1)COC(C=C3)=CC=C3OC4=CC=CC=C4
Renhedsgrad noter Research
Molekylær formel C28H25NO6
Til brug med (applikation) COVID-19-immunoregulation