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Imidazopyridiner

Organiske heterocykliske forbindelser, der indeholder en imidazolring fusioneret til en pyridinring. Imidazol er en femleddet ring med tre carbonatomer og to nitrogenatomer; pyridin er en seksleddet ring med fem carbonatomer og et nitrogenatom.

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1 – 13 af 13 Resultater
1

Pumaprazole, MedChemExpress

MedChemExpress Pumaprazole is a reversible proton pump antagonist.

ENCOMPASS_PREFERRED
Kemisk navn eller materiale Pumaprazole
Formel vægt 338.4
Opløselighedsinformation DMSO : 100 mg/mL (295.51 mM; Need ultrasonic)
Procent renhed 99.9%
Fysisk form Solid
Farve Light Yellow
Grad Research
Anbefalet opbevaring Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol) 338.4
CAS 158364-59-1
Synonym BY-841
Holdbarhed Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL O=C(OC)NC1=CC=CC(C)=C1CNC2=CC=CN3C2=NC(C)=C3C
Renhedsgrad noter Research
Molekylær formel C19H22N4O2
Til brug med (applikation) COVID-19-immunoregulation
2

Linaprazan, MedChemExpress

MedChemExpress Linaprazan (AZD0865) inhibits gastric H+,K+-ATPase by K+-competitive binding.

ENCOMPASS_PREFERRED
Kemisk navn eller materiale Linaprazan
Formel vægt 366.46
Opløselighedsinformation DMSO : ≥ 35 mg/mL (95.51 mM)
Procent renhed 98.8%
Fysisk form Solid
Farve White
Grad Research
Anbefalet opbevaring Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol) 366.46
CAS 248919-64-4
Synonym AZD0865
Holdbarhed Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL O=C(C1=CN2C(C(NCC3=C(C)C=CC=C3C)=C1)=NC(C)=C2C)NCCO
Renhedsgrad noter Research
Molekylær formel C21H26N4O2
Til brug med (applikation) Cancer-programmed cell death
3

IRAK inhibitor 1, MedChemExpress

MedChemExpress IRAK inhibitor 1 is a potent IRAK-4 inhibitor with IC50 of 216 nM, is poorly active against JNK-1 and JNK-2 with IC50 of 3.801 μM, and >10 μM, respectively.

ENCOMPASS_PREFERRED
Kemisk navn eller materiale IRAK inhibitor 1
Formel vægt 293.37
Opløselighedsinformation DMSO : 16.67 mg/mL (56.82 mM; Need ultrasonic)
Procent renhed 98.05%
Fysisk form Solid
Farve Light Yellow
Grad Research
Anbefalet opbevaring Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol) 293.37
CAS 1042224-63-4
Holdbarhed Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL C1(C2=CN=C3N2C=CC=C3)=CC=CC(NC4CCNCC4)=N1
Renhedsgrad noter Research
Molekylær formel C17H19N5
Til brug med (applikation) COVID-19-immunoregulation
4

Savolitinib, MedChemExpress

MedChemExpress Savolitinib (AZD-6094) is a potent, highly selective, and orally bioavailable c-Met inhibitor with IC50 s of 5 nM and 3 nM for c-Met and p-Met, respectively. Savolitinib (AZD-6094) selectively binds to and inhibits the activation of c-Met in an ATP-competitive manner, and disrupts c-Met signal transduction pathways. Antineoplastic activity.

ENCOMPASS_PREFERRED
Kemisk navn eller materiale Savolitinib
Formel vægt 345.36
Opløselighedsinformation DMSO : 25 mg/mL (72.39 mM; Need ultrasonic)
Procent renhed 98.45%
Fysisk form Solid
Farve Off-White
Grad Research
Anbefalet opbevaring Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol) 345.36
CAS 1313725-88-0
Synonym Volitinib HMPL-504 AZD-6094
Holdbarhed Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL CN1N=CC(C2=CN=C3C(N([C@H](C4=CN5C(C=C4)=NC=C5)C)N=N3)=N2)=C1
Renhedsgrad noter Research
Molekylær formel C17H15N9
Til brug med (applikation) Cancer-Kinase/protease
5

PDE10-IN-1, MedChemExpress

MedChemExpress PDE10-IN-1 is a potent PDE10-IN-1 inhibitor extracted from Patent WO 2013192273 A1, for treating CNS and metabolic disorders.

ENCOMPASS_PREFERRED
Kemisk navn eller materiale PDE10-IN-1
Formel vægt 369.42
Opløselighedsinformation DMSO : 2 mg/mL (5.41 mM; Need ultrasonic)
Procent renhed 97.82%
Fysisk form Solid
Farve Earth Yellow
Grad Research
Anbefalet opbevaring Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol) 369.42
CAS 1516896-09-5
Holdbarhed Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL CC1=C([C@H]2[C@H](C3=NN4C(C(C)=NC=C4C)=N3)C2)N=C5C6=C(N=CC=C6)C=CN51
Renhedsgrad noter Research
Molekylær formel C21H19N7
Til brug med (applikation) Neuroscience-Neuromodulation
6

CXCR7 modulator 2, MedChemExpress

MedChemExpress CXCR7 modulator 2 is a modulator of C-X-C Chemokine Receptor Type 7 (CXCR7), with a Ki of 13 nM.

ENCOMPASS_PREFERRED
Kemisk navn eller materiale CXCR7 modulator 2
Formel vægt 522.68
Opløselighedsinformation DMSO : 250 mg/mL (478.30 mM; Need ultrasonic)
Procent renhed 98.39%
Fysisk form Solid
Farve Light Yellow
Grad Research
Anbefalet opbevaring Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol) 522.68
CAS 2227426-37-9
Holdbarhed Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL O=C([C@@H]1[C@H](O2)CC[C@H]2C1)N3CCC([C@H](CC(N)=O)N4CCCN(C5=C(CC)C=CN6C5=NC=C6)CC4)CC3
Renhedsgrad noter Research
Molekylær formel C29H42N6O3
Til brug med (applikation) Neuroscience-Neuromodulation
7

Dipraglurant, MedChemExpress

MedChemExpress Dipraglurant (ADX48621) is a potent, selective, orally active and brain penetrant mGluR5 negative allosteric modulator (NAM), with an IC50 of 21 nM. Dipraglurant can reduce Levodopa-induced dyskinesia (LID) in vivo.

ENCOMPASS_PREFERRED
Kemisk navn eller materiale Dipraglurant
Formel vægt 265.29
Opløselighedsinformation DMSO : ≥ 40 mg/mL (150.78 mM)
Procent renhed 95.95%
Fysisk form Solid
Farve White
Grad Research
Anbefalet opbevaring Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol) 265.29
CAS 872363-17-2
Synonym ADX48621
Holdbarhed Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL FC1=CN2C(C=C1)=NC(CCC#CC3=NC=CC=C3)=C2
Renhedsgrad noter Research
Molekylær formel C16H12FN3
Til brug med (applikation) Neuroscience-Neurodegeneration
8

Antitumor agent-3, MedChemExpress

MedChemExpress Antitumor agent-3 is a potent compound which comprises a new imidazopyridine having excellent antitumor activity as an active ingredient.

ENCOMPASS_PREFERRED
Kemisk navn eller materiale Antitumor agent-3
Formel vægt 428.35
Opløselighedsinformation DMSO : ≥ 59 mg/mL (137.74 mM)
Procent renhed 99.71%
Fysisk form Solid
Farve Off-White
Grad Research
Anbefalet opbevaring Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol) 428.35
CAS 420126-30-3
Holdbarhed Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL FC(C1=CC=C(NC2=NC(C3=C(C(F)(F)F)N=C4C=CC=CN43)=CS2)C=C1)(F)F
Renhedsgrad noter Research
Molekylær formel C18H10F6N4S
Til brug med (applikation) Cancer-programmed cell death
9

Soraprazan, MedChemExpress

MedChemExpress Soraprazan (BYK61359) is a selective, reversible K-competitive inhibitor of the H,K-ATPase (Ki=6.4 nM), with an IC50 of 0.19 μM in gastric glands. Soraprazan binds to the H,K-ATPase with a Kd of 28.27 nM. Soraprazan shows immediate inhibition of acid secretion and is more than 2000-fold selective for H,K-ATPase over Na,K- and Ca-ATPases.

ENCOMPASS_PREFERRED
Kemisk navn eller materiale Soraprazan
Formel vægt 367.44
Opløselighedsinformation DMSO : ≥ 150 mg/mL (408.23 mM)
Procent renhed 99.69%
Fysisk form Solid
Farve Light Yellow
Grad Research
Anbefalet opbevaring Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol) 367.44
CAS 261944-46-1
Synonym BYK61359
Holdbarhed Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL O[C@@H]1[C@@H](C2=CC=CC=C2)NC3=C(C=CN4C3=NC(C)=C4C)[C@H]1OCCOC
Renhedsgrad noter Research
Molekylær formel C21H25N3O3
10

JK184, MedChemExpress

MedChemExpress JK184 is a potent Hedgehog (Hh) pathway inhibitor with IC50 of 30 nM in mammalian cells.

ENCOMPASS_PREFERRED
Kemisk navn eller materiale JK184
Sundhedsfare 1 H302∣H315∣H319∣H335
Formel vægt 350.44
Opløselighedsinformation DMSO : ≥ 50 mg/mL (142.68 mM)
Procent renhed 99.37%
Fysisk form Solid
Farve Pink
Grad Research
Anbefalet opbevaring Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol) 350.44
CAS 315703-52-7
Holdbarhed Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL CC1=C(C2=CSC(NC3=CC=C(OCC)C=C3)=N2)N4C=CC=CC4=N1
Renhedsgrad noter Research
Molekylær formel C19H18N4OS
Til brug med (applikation) Cancer-programmed cell death
11

Serabelisib, MedChemExpress

MedChemExpress Serabelisib (MLN1117) is a selective p110α inhibitor with an IC50 of 15 nM.

ENCOMPASS_PREFERRED
Kemisk navn eller materiale Serabelisib
Formel vægt 363.37
Opløselighedsinformation DMSO : 6.4 mg/mL (17.61 mM; Need ultrasonic and warming)
Procent renhed 98.1%
Fysisk form Solid
Farve Gray
Grad Research
Anbefalet opbevaring Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol) 363.37
CAS 1268454-23-4
Synonym MLN1117 INK1117 TAK-117
Holdbarhed Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL O=C(C1=CN=C2C=CC(C3=CC=C(OC(N)=N4)C4=C3)=CN21)N5CCOCC5
Renhedsgrad noter Research
Molekylær formel C19H17N5O3
Til brug med (applikation) Cancer-Kinase/protease
12

DGAT1-IN-1, MedChemExpress

MedChemExpress DGAT1-IN-1 is a potent DGAT1 inhibitor with IC50 of < 10 nM(cell lysate from Hep3B cells overexpressing human DGAT1).

ENCOMPASS_PREFERRED
Kemisk navn eller materiale DGAT1-IN-1
Formel vægt 551.56
Opløselighedsinformation DMSO : 20 mg/mL (36.26 mM; Need ultrasonic)
Procent renhed 95.0%
Fysisk form Solid
Farve White
Grad Research
Anbefalet opbevaring Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol) 551.56
CAS 1449779-49-0
Holdbarhed Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL OC(C[C@H]1CC[C@H](C2=CC=C(C3=CN4C=C(C(NCC5=CC=C(OC(F)(F)F)C=C5)=O)N=C4C=C3)C=C2)CC1)=O
Renhedsgrad noter Research
Molekylær formel C30H28F3N3O4
Til brug med (applikation) Metabolism-sugar/lipid metabolism
13

Olprinone Hydrochloride, MedChemExpress

MedChemExpress Olprinone (Loprinone) Hydrochloride is a potent phosphodiesterase (PDE) 3 inhibitor, with IC50s of 150, 100, 0.35 and 14 μM for PDE1, PDE2, PDE3 and PDE4, respectively. Olprinone Hydrochloride is used for the research of heart failure due to its positive inotropic and vasodilative effects. Anti-inflammatory activity.

ENCOMPASS_PREFERRED
Kemisk navn eller materiale Olprinone Hydrochloride
Sundhedsfare 1 H315∣H319∣H335
Formel vægt 286.72
Opløselighedsinformation H2O : ≥ 7.69 mg/mL (26.82 mM)
Procent renhed 99.91%
Fysisk form Solid
Farve Off-White
Grad Research
Anbefalet opbevaring 4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Molekylvægt (g/mol) 286.72
CAS 119615-63-3
Synonym Loprinone Hydrochloride
Holdbarhed 4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
SMIL CC(N1)=C(C=C(C#N)C1=O)C2=CN3C(C=C2)=NC=C3.[H]Cl
Renhedsgrad noter Research
Molekylær formel C14H11ClN4O
Til brug med (applikation) COVID-19-immunoregulation