Trifluoreddikesyre
Trifluoreddikesyre er en ætsende organofluorforbindelse, der er strukturelt analog med, men stærkere end eddikesyre. Tilgængelig i forskellige mængder og reagenskvaliteter, det bruges i NMR-spektroskopi, massespektrometri, organisk syntese osv.
Næsten 100.000 gange mere sur end eddikesyre, TFA er meget udbredt i organisk kemi. TFA bruges som reagens i organisk syntese på grund af dets egenskaber: flygtighed, organisk opløsningsmiddelopløselighed og sur styrke. Det er mindre oxiderende end svovlsyre og er lettere tilgængeligt i sin vandfri form end nogle andre syrer. Andre funktioner omfatter:
- Anvendes i syrekatalyserede reaktioner, især peptidsyntese (til at spalte estere)
- Opløser protein, når det blandes
- med flydende SO 2 Fjerner t -butyl-afledte sidekæde-beskyttelsesgrupper
- i Fmoc-peptidsyntese Kan fjerne t -butoxycarbonyl-beskyttende
- gruppe i organisk syntese Ved lave koncentrationer, fungerer som et ion-parrende middel for peptider og
- små proteiner i væskekromatografi med organiske forbindelser. Til syrestabile materialer,
- kan være et opløsningsmiddel til
- NMR-spektroskopi. Fungerer som kalibreringsmiddel
- i massespektrometri Anvendes til fremstilling af
trifluoracetatsalte. baser og metaller, især letmetaller, sker der en kraftig eksoterm reaktion. Når det blandes med lithiumaluminiumhydrid (LAH), er reaktionen eksplosiv.
Selvom det ikke er brændbart, er TFA ætsende for hud, øjne og slimhinder og kræver omhyggelig brug og håndtering. Det er skadeligt ved indånding, forårsager alvorlige hudforbrændinger og øjenskader og er giftigt for vandlevende organismer i selv lave koncentrationer.
TFA er også et produkt af den metaboliske nedbrydning af anæstesimidlet halothan. Det er den mistænkte årsag til halothan-induceret hepatitis.
Trifluoreddikesyre, 99,5 %, for biokemi
CAS: 76-05-1 Molekylær formel: C2HF3O2 Molekylvægt (g/mol): 114.02 MDL nummer: MFCD00004169 InChI nøgle: DTQVDTLACAAQTR-UHFFFAOYSA-N Synonym: trifluoroacetic acid,perfluoroacetic acid,trifluoroethanoic acid,trifluoroacetic acid,acetic acid, trifluoro,trifluoroaceticacid,cf3cooh,trifluoro acetic acid,trifluoro-acetic acid,kyselina trifluoroctova PubChem CID: 6422 ChEBI: CHEBI:45892 IUPAC navn: trifluoreddikesyre SMIL: OC(=O)C(F)(F)F
Trifluoreddikesyre, 99+%, for HPLC
CAS: 76-05-1 Molekylær formel: C2HF3O2 Molekylvægt (g/mol): 114.02 MDL nummer: MFCD00004169 InChI nøgle: DTQVDTLACAAQTR-UHFFFAOYSA-N Synonym: trifluoroacetic acid,perfluoroacetic acid,trifluoroethanoic acid,trifluoroacetic acid,acetic acid, trifluoro,trifluoroaceticacid,cf3cooh,trifluoro acetic acid,trifluoro-acetic acid,kyselina trifluoroctova PubChem CID: 6422 ChEBI: CHEBI:45892 IUPAC navn: 2,2,2-trifluoreddikesyre SMIL: OC(=O)C(F)(F)F
Trifluoreddikesyre, 99%
CAS: 76-05-1 Molekylær formel: C2HF3O2 Molekylvægt (g/mol): 114.02 MDL nummer: MFCD00004169 InChI nøgle: DTQVDTLACAAQTR-UHFFFAOYSA-N Synonym: trifluoroacetic acid,perfluoroacetic acid,trifluoroethanoic acid,trifluoroacetic acid,acetic acid, trifluoro,trifluoroaceticacid,cf3cooh,trifluoro acetic acid,trifluoro-acetic acid,kyselina trifluoroctova PubChem CID: 6422 ChEBI: CHEBI:45892 IUPAC navn: trifluoreddikesyre SMIL: OC(=O)C(F)(F)F
Thermo Scientific Chemicals Trifluoreddikesyre, biokemisk kvalitet, 99,5+%
CAS: 76-05-1 Molekylær formel: C2HF3O2 Molekylvægt (g/mol): 114.02 MDL nummer: MFCD00004169 InChI nøgle: DTQVDTLACAAQTR-UHFFFAOYSA-N Synonym: trifluoroacetic acid,perfluoroacetic acid,trifluoroethanoic acid,trifluoroacetic acid,acetic acid, trifluoro,trifluoroaceticacid,cf3cooh,trifluoro acetic acid,trifluoro-acetic acid,kyselina trifluoroctova PubChem CID: 6422 ChEBI: CHEBI:45892 IUPAC navn: trifluoreddikesyre SMIL: OC(=O)C(F)(F)F
Trifluoreddikesyre, 99+%, til HPLC, Fisher Chemical™
CAS: 76-05-1 Molekylær formel: C2HF3O2 Molekylvægt (g/mol): 114.02 MDL nummer: MFCD00004169 InChI nøgle: DTQVDTLACAAQTR-UHFFFAOYSA-N Synonym: trifluoroacetic acid,perfluoroacetic acid,trifluoroethanoic acid,trifluoroacetic acid,acetic acid, trifluoro,trifluoroaceticacid,cf3cooh,trifluoro acetic acid,trifluoro-acetic acid,kyselina trifluoroctova PubChem CID: 6422 ChEBI: CHEBI:45892 SMIL: OC(=O)C(F)(F)F
Trifluoreddikesyre, Extra Pure, SLR, Fisher Chemical
Trifluoreddikesyre, HPLC-kvalitet, 99,5+%
CAS: 76-05-1 Molekylær formel: C2HF3O2 Molekylvægt (g/mol): 114.02 MDL nummer: MFCD00004169 InChI nøgle: DTQVDTLACAAQTR-UHFFFAOYSA-N Synonym: trifluoroacetic acid,perfluoroacetic acid,trifluoroethanoic acid,trifluoroacetic acid,acetic acid, trifluoro,trifluoroaceticacid,cf3cooh,trifluoro acetic acid,trifluoro-acetic acid,kyselina trifluoroctova PubChem CID: 6422 ChEBI: CHEBI:45892 IUPAC navn: 2,2,2-trifluoreddikesyre SMIL: OC(=O)C(F)(F)F
Trifluoreddikesyre, 98%, Thermo Scientific™
CAS: 76-05-1 Molekylær formel: C2HF3O2 Molekylvægt (g/mol): 114.02 MDL nummer: MFCD00004169 InChI nøgle: DTQVDTLACAAQTR-UHFFFAOYSA-N Synonym: TFA IUPAC navn: trifluoreddikesyre SMIL: OC(=O)C(F)(F)F
Trifluoreddikesyre, Optima™ LC/MS klasse, Fisher Chemical™
CAS: 76-05-1 Molekylær formel: C2HF3O2 Molekylvægt (g/mol): 114.02 MDL nummer: MFCD00004169 InChI nøgle: DTQVDTLACAAQTR-UHFFFAOYSA-N Synonym: trifluoroacetic acid,perfluoroacetic acid,trifluoroethanoic acid,trifluoroacetic acid,acetic acid, trifluoro,trifluoroaceticacid,cf3cooh,trifluoro acetic acid,trifluoro-acetic acid,kyselina trifluoroctova PubChem CID: 6422 ChEBI: CHEBI:45892 IUPAC navn: trifluoreddikesyre SMIL: OC(=O)C(F)(F)F
Trifluoreddikesyre, 99+%, ekstra ren
CAS: 76-05-1 Molekylær formel: C2HF3O2 Molekylvægt (g/mol): 114.02 MDL nummer: MFCD00004169 InChI nøgle: DTQVDTLACAAQTR-UHFFFAOYSA-N Synonym: trifluoroacetic acid,perfluoroacetic acid,trifluoroethanoic acid,trifluoroacetic acid,acetic acid, trifluoro,trifluoroaceticacid,cf3cooh,trifluoro acetic acid,trifluoro-acetic acid,kyselina trifluoroctova PubChem CID: 6422 ChEBI: CHEBI:45892 SMIL: OC(=O)C(F)(F)F
Trifluoreddikesyre, 99%
CAS: 76-05-1 Molekylær formel: C2HF3O2 Molekylvægt (g/mol): 114.02 MDL nummer: MFCD00004169 InChI nøgle: DTQVDTLACAAQTR-UHFFFAOYSA-N Synonym: trifluoroacetic acid,perfluoroacetic acid,trifluoroethanoic acid,trifluoroacetic acid,acetic acid, trifluoro,trifluoroaceticacid,cf3cooh,trifluoro acetic acid,trifluoro-acetic acid,kyselina trifluoroctova PubChem CID: 6422 ChEBI: CHEBI:45892 IUPAC navn: trifluoreddikesyre SMIL: OC(=O)C(F)(F)F
Trifluoreddikesyre, 99,5+%
CAS: 76-05-1 Molekylær formel: C2HF3O2 Molekylvægt (g/mol): 114.02 MDL nummer: MFCD00004169 InChI nøgle: DTQVDTLACAAQTR-UHFFFAOYSA-N Synonym: trifluoroacetic acid,perfluoroacetic acid,trifluoroethanoic acid,trifluoroacetic acid,acetic acid, trifluoro,trifluoroaceticacid,cf3cooh,trifluoro acetic acid,trifluoro-acetic acid,kyselina trifluoroctova PubChem CID: 6422 ChEBI: CHEBI:45892 IUPAC navn: trifluoreddikesyre SMIL: OC(=O)C(F)(F)F
Angiotensin II Trifluoreddikesyresalt (Human), TRC
Molekylær formel: C50H71N13O12 . x(C 2HF3O2) Synonym: N-[1-[N-[N-[N-[N-(N2-L-α-Aspartyl-L-arginyl)-L-valyl]-L-tyrosyl]-L-isoleucyl]-L-histidyl]-L-prolyl]-L-phenylalanine,[Ile5]-Ang II,[Ile5]-Angiotensin II,5-L-Isoleucineangiotensin II,10: PN: US20130023475 SEQID: 17 unclaimed protein,10: PN: WO0212471 SEQID: 17 unclaimed sequence,113: PN: WO2008104000 TABLE: 4 unclaimed sequence,11: PN: US20030119021 SEQID: 10 unclaimed sequence,1272: PN: US20050069911 SEQID: 1272 unclaimed sequence,12: PN: US20090088553 SEQID: 86 unclaimed protein,12: PN: WO0239997 SEQID: 17 unclaimed sequence,134: PN: WO02098448 SEQID: 144 unclaimed sequence,134: PN: WO02098906 SEQID: 144 unclaimed sequence,13: PN: US20120071544 SEQID: 7 unclaimed sequence,14: PN: WO2004007538 SEQID: 13 claimed sequence,14: PN: WO2011020056 SEQID: 95 claimed protein,154: PN: WO2009126292 TABLE: 4 unclaimed sequence,17: PN: US6610497 SEQID: 17 unclaimed sequence,17: PN: US6884771 SEQID: 17 unclaimed sequence,31: PN: WO0198325 SEQID: 32 claimed protein,32: PN: US20060014212 SEQID: 32 unclaimed sequence,32: PN: WO0056345 SEQID: 32 claimed sequence,7: PN: JP2005291836 SEQID: 6 unclaimed protein,7: PN: US20040209344 SEQID: 2 unclaimed sequence,7: PN: WO03072059 SEQID: 8 unclaimed sequence,80: PN: US6017693 TABLE: 4 claimed sequence,83: PN: US20050009742 PAGE: 21 claimed sequence,85: PN: US20080213898 SEQID: 83 claimed sequence,873: PN: US20040180380 SEQID: 1272 unclaimed sequence,8: PN: WO2008138350 SEQID: 8 claimed sequence,8: PN: WO9958140 SEQID: 1 claimed protein,96: PN: WO2008058016 SEQID: 96 claimed protein,9: PN: WO2008005531 SEQID: 17 unclaimed sequence,9: PN: WO2008106043 TABLE: 6 claimed protein,Angiotensin 2,Angiotensin II,Angiotensin II (human),Angiotensin II (mouse),Angiotensin II [Ile5],Asp-Arg-Val-Tyr-Ile-His-Pro-Phe,Asp1-Ile5-angiotensin II,Human angiotensin II,Ileu5-angiotensin II,Isoleucyl5-angiotensin II IUPAC navn: (2S,5S,8S,11S,14S,17S)-2-((1H-imidazol-4-yl)methyl)-17-amino-5-((S)-sec-butyl)-1-((S)-2-(((S)-1-carboxy-2-phenylethyl)carbamoyl)pyrrolidin-1-yl)-14-(3-guanidinopropyl)-8-(4-hydroxybenzyl)-11-isopropyl-1,4,7,10,13,16-hexaoxo-3,6,9,12,15-pentaazanonadecan-19-oic syre2,2,2-trifluoroeddikesyre SMIL: O=C(O)[C@H](CC1=CC=CC=C1)NC([C@H]2N(C([C@H](CC3=CNC=N3)NC([C@H]([C@@H](C)CC)NC([C@H](CC4=CC=C(C=C4)O)NC([C@H](C(C)C)NC([C@H](CCCNC(N)=N)NC([C@H](CC(O)=O)N)=O)=O)=O)=O)=O)=O)CCC2)=O.OC(C(F)(F)F)=O.[F,Cl,Br,I]
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