Small interfering RNA/silencing RNA (siRNA) is a class of double-stranded, non-coding RNA molecule, 20-25 base pairs in length. As part of the RNA interference pathway, it regulates gene expression by degrading mRNA after transcription, preventing translation.
Silencer™ Select siRNAs are classic 21-mers which incorporate the latest improvements in siRNA design, off-target effect prediction algorithms, and chemistry.
Silencer™ Select siRNAs are the result of recent improvements in siRNA design combined with novel chemical modifications yielding unrivaled knockdown efficiency and specificity. Our best performing siRNA for cell culture work. Silencer™ siRNAs are unmodified 21 nucleotide siRNAs that have been designed with an older, yet rigorously tested design algorithm. A lower cost alternative to Silencer™ Select siRNAs, but without some of the performance enhancements.
Silencer™ custom siRNAs (unmodified 21-bp duplexes) are cost-effective RNA interference (RNAi) tools ideal for knocking down gene expression in order to study protein function in a wide range of cell types.
The Silencer™ Human Apoptosis siRNA Library provides investigators with a focused siRNA screening platform targeting apoptosis genes and enabling a detailed analysis of the apoptotic signaling pathway.
The nuclear hormone receptor gene family includes receptors for thyroid and steroid hormones, retinoids and vitamin D, as well as receptors of unknown ligands.
DNA surveillance proteins monitor DNA integrity, and they can activate cell cycle checkpoints and DNA repair pathways in response to DNA damage. This can prevent potentially deleterious mutations.