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Pyraziner

Aromatiske organiske heterocykliske forbindelser, der består af en seksleddet ring med fire carbonatomer og to nitrogenatomer i modsatte positioner af ringen, hvilket gør denne ring symmetrisk.

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1 – 15 af 17 Resultater
1

6-Biopterin, MedChemExpress

MedChemExpress 6-Biopterin (L-Biopterin), a pterin derivative, is a NO synthase cofactor.

ENCOMPASS_PREFERRED
Kemisk navn eller materiale 6-Biopterin
Sundhedsfare 1 H315∣H319∣H335
Formel vægt 237.22
Opløselighedsinformation DMSO : 12.5 mg/mL (52.69 mM; ultrasonic and warming and heat to 75°C)
Procent renhed 97.0%
Fysisk form Solid
Farve White
Grad Research
Anbefalet opbevaring 4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Molekylvægt (g/mol) 237.22
CAS 22150-76-1
Synonym L-Biopterin
Holdbarhed 4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
SMIL O=C1N=C(N)NC2=NC=C([C@@H](O)[C@@H](O)C)N=C12
Renhedsgrad noter Research
Molekylær formel C9H11N5O3
Til brug med (applikation) Cancer-programmed cell death
2

EIPA, MedChemExpress

MedChemExpress EIPA (L593754) is an orally active TRPP3 channel inhibitor with an IC50 of 10.5 μM. EIPA also enhances autophagy by inhibiting Na+/H+-exchanger 3 (NHE3). EIPA inhibits macropinocytosis as well. EIPA can be used in the research of inflammation and cancers, such as gastric cancer, colon carcinoma, pancreatic carcinoma.

ENCOMPASS_PREFERRED
Kemisk navn eller materiale EIPA
Sundhedsfare 1 H315∣H319∣H335
Formel vægt 299.76
Opløselighedsinformation DMSO : 140 mg/mL (467.04 mM; Need ultrasonic)
Procent renhed 98.0%
Fysisk form Solid
Farve Yellow
Grad Research
Anbefalet opbevaring Powder -20°C 3 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol) 299.76
CAS 1154-25-2
Synonym L593754 MH 12-43
Holdbarhed Powder -20°C 3 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL O=C(C1=NC(Cl)=C(N(CC)C(C)C)N=C1N)NC(N)=N
Renhedsgrad noter Research
Molekylær formel C11H18ClN7O
Til brug med (applikation) Cancer-programmed cell death
3

HSR6071, MedChemExpress

MedChemExpress HSR6071, a pyrazinecarboxamide derivative, is an orally active and potent antiallergic agent. HSR6071 potently inhibits the experimental asthma in rat models.

ENCOMPASS_PREFERRED
Kemisk navn eller materiale HSR6071
Formel vægt 260.26
Opløselighedsinformation H2O : 50 mg/mL (192.12 mM; ultrasonic and adjust pH to 12 with NaOH)
Procent renhed 98.51%
Fysisk form Powder
Farve Light Yellow
Grad Research
Anbefalet opbevaring Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol) 260.26
CAS 111374-21-1
Holdbarhed Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL O=C(C1=NC(N2CCCC2)=CN=C1)NC3=NN=NN3
Renhedsgrad noter Research
Molekylær formel C10H12N8O
Til brug med (applikation) COVID-19-immunoregulation
4

AZD7687, MedChemExpress

MedChemExpress AZD7687 is a potent, selective, reversible and orally active diacylglycerol acyltransferase 1 (DGAT1) inhibitor with an IC50 of 80 nM for human DGAT1. AZD7687 can be used for type 2 diabetes mellitus and obesity research.

ENCOMPASS_PREFERRED
Kemisk navn eller materiale AZD7687
Formel vægt 367.44
Opløselighedsinformation DMSO : ≥ 50 mg/mL (136.08 mM)
Procent renhed 99.04%
Fysisk form Solid
Farve Pink
Grad Research
Anbefalet opbevaring Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol) 367.44
CAS 1166827-44-6
Holdbarhed Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL CC1=C(C(N)=O)N=C(C2=CC=C([C@H]3CC[C@H](CC(O)=O)CC3)C=C2)C(C)=N1
Renhedsgrad noter Research
Molekylær formel C21H25N3O3
Til brug med (applikation) Metabolism-sugar/lipid metabolism
5

5-(N,N-Hexamethylene)-amiloride, MedChemExpress

MedChemExpress 5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) derives from an amiloride and is a potent Na+/H+ exchanger inhibitor, which decreases the intracellular pH (pHi) and induces apoptosis in leukemic cells.

ENCOMPASS_PREFERRED
Kemisk navn eller materiale 5-(N,N-Hexamethylene)-amiloride
Formel vægt 311.77
Opløselighedsinformation DMSO : 100 mg/mL (320.75 mM; Need ultrasonic)
Procent renhed 98.0%
Fysisk form Powder
Farve Light Yellow
Grad Research
Anbefalet opbevaring Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol) 311.77
CAS 1428-95-1
Synonym Hexamethylene amiloride HMA
Holdbarhed Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL O=C(C1=NC(Cl)=C(N2CCCCCC2)N=C1N)NC(N)=N
Renhedsgrad noter Research
Molekylær formel C12H18ClN7O
Til brug med (applikation) Cancer-programmed cell death
6

BG45, MedChemExpress

MedChemExpress BG45 is an HDAC class I inhibitor with selectivity for HDAC3 (IC50 = 289 nM).

ENCOMPASS_PREFERRED
Kemisk navn eller materiale BG45
Sundhedsfare 1 H302∣H315∣H319∣H335
Formel vægt 214.22
Opløselighedsinformation DMSO : ≥ 48 mg/mL (224.07 mM)
Procent renhed 99.95%
Fysisk form Solid
Farve Yellow
Grad Research
Anbefalet opbevaring Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol) 214.22
CAS 926259-99-6
Holdbarhed Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL O=C(C1=NC=CN=C1)NC2=CC=CC=C2N
Renhedsgrad noter Research
Molekylær formel C11H10N4O
Til brug med (applikation) Cancer-programmed cell death
7

Acipimox, MedChemExpress

MedChemExpress Acipimox (K-9321), a nicotinic acid analogue, is an antilipolytic compound. Acipimox stimulates leptin releas, inhibits lipolysis and suppresses systemic levels of free fatty acids (FFAs) and improves insulin sensitivity.

ENCOMPASS_PREFERRED
Kemisk navn eller materiale Acipimox
Formel vægt 154.12
Opløselighedsinformation DMSO : ≥ 100 mg/mL (648.85 mM) ∣H2O : 20 mg/mL (129.77 mM; Need ultrasonic)
Procent renhed 99.0%
Fysisk form Solid
Farve Off-White
Grad Research
Anbefalet opbevaring Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol) 154.12
CAS 51037-30-0
Synonym K-9321
Holdbarhed Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL O=C(C1=C[N+]([O-])=C(C)C=N1)O
Renhedsgrad noter Research
Molekylær formel C6H6N2O3
Til brug med (applikation) COVID-19-immunoregulation
8

Caficrestat, MedChemExpress

MedChemExpress Caficrestat (Aldose reductase-IN-1) is a inhibitor of aldose reductase with IC50 of 28.9 pM.

ENCOMPASS_PREFERRED
Kemisk navn eller materiale Caficrestat
Formel vægt 421.35
Opløselighedsinformation DMSO : ≥ 28 mg/mL (66.45 mM)
Procent renhed 99.88%
Fysisk form Solid
Farve White
Grad Research
Anbefalet opbevaring Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol) 421.35
CAS 1355612-71-3
Synonym Aldose reductase-IN-1 AT-001
Holdbarhed Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL O=C1C2=NC=CN=C2C(CC(O)=O)=NN1CC3=NC4=C(C=CC(C(F)(F)F)=C4)S3
Renhedsgrad noter Research
Molekylær formel C17H10F3N5O3S
Til brug med (applikation) Metabolism-sugar/lipid metabolism
9

VE-821, MedChemExpress

MedChemExpress VE-821 is a potent ATP-competitive inhibitor of ATR with Ki/IC50 of 13 nM/26 nM.

ENCOMPASS_PREFERRED
Kemisk navn eller materiale VE-821
Formel vægt 368.41
Opløselighedsinformation DMSO : 50 mg/mL (135.72 mM; Need ultrasonic) ∣H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)
Procent renhed 98.94%
Fysisk form Solid
Farve Green
Grad Research
Anbefalet opbevaring Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol) 368.41
CAS 1232410-49-9
Holdbarhed Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL O=C(NC1=CC=CC=C1)C2=NC(C3=CC=C(C=C3)S(=O)(C)=O)=CN=C2N
Renhedsgrad noter Research
Molekylær formel C18H16N4O3S
Til brug med (applikation) Cancer-Kinase/protease
10

Amiloride hydrochloride, MedChemExpress

MedChemExpress Amiloride hydrochloride (MK-870 hydrochloride) is an inhibitor of both epithelial sodium channel (ENaC) and urokinase-type plasminogen activator receptor (uTPA). Amiloride hydrochloride is a blocker of polycystin-2 (PC2; TRPP2) channel.

ENCOMPASS_PREFERRED
Kemisk navn eller materiale Amiloride hydrochloride
Formel vægt 266.09
Opløselighedsinformation DMSO : ≥ 100 mg/mL (375.81 mM) ∣H2O : 7.14 mg/mL (26.83 mM; Need ultrasonic)
Procent renhed 99.46%
Fysisk form Solid
Farve Light Yellow
Grad Research
Anbefalet opbevaring 4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Molekylvægt (g/mol) 266.09
CAS 2016-88-8
Synonym MK-870 hydrochloride
Holdbarhed 4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
SMIL O=C(C1=NC(Cl)=C(N)N=C1N)NC(N)=N.Cl
Renhedsgrad noter Research
Molekylær formel C6H9Cl2N7O
Til brug med (applikation) Metabolism-protein/nucleotide metabolism
11

Naquotinib mesylate, MedChemExpress

MedChemExpress Naquotinib mesylate (ASP8273 mesylate) is an orally available, mutant-selective and irreversible EGFR inhibitor; with IC50s of 8-33 nM toward EGFR mutants and 230 nM for EGFR.

ENCOMPASS_PREFERRED ENCOMPASS
Kemisk navn eller materiale Naquotinib mesylate
Formel vægt 658.81
Opløselighedsinformation DMSO : 12.5 mg/mL (18.97 mM; Need ultrasonic and warming)
Procent renhed 98.02%
Fysisk form Solid
Farve Yellow
Grad Research
Anbefalet opbevaring 4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Molekylvægt (g/mol) 658.81
CAS 1448237-05-5
Synonym ASP8273 (mesylate)
Holdbarhed 4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
SMIL O=C(C1=NC(CC)=C(O[C@H]2CN(C(C=C)=O)CC2)N=C1NC3=CC=C(N4CCC(N5CCN(C)CC5)CC4)C=C3)N.CS(=O)(O)=O
Renhedsgrad noter Research
Molekylær formel C31H46N8O6S
Til brug med (applikation) Cancer-Kinase/protease
12

Gilteritinib, MedChemExpress

MedChemExpress Gilteritinib (ASP2215) is a potent and ATP-competitive FLT3/AXL inhibitor with IC50s of 0.29 nM/0.73 nM, respectively.

ENCOMPASS_PREFERRED
Kemisk navn eller materiale Gilteritinib
Formel vægt 552.71
Opløselighedsinformation Ethanol : 100 mg/mL (180.93 mM; ultrasonic and adjust pH to 2 with HCl) ∣DMSO : 2 mg/mL (3.62 mM; Need ultrasonic)
Procent renhed 97.77%
Fysisk form Solid
Farve Light Yellow
Grad Research
Anbefalet opbevaring 4°C, stored under nitrogen∣In solvent : -80°C, 6 months∣-20°C, 1 month (stored under nitrogen)
Molekylvægt (g/mol) 552.71
CAS 1254053-43-4
Synonym ASP2215
Holdbarhed 4°C, stored under nitrogen∣In solvent : -80°C, 6 months∣-20°C, 1 month (stored under nitrogen)
SMIL NC(C1=NC(CC)=C(NC2CCOCC2)N=C1NC3=CC(OC)=C(N4CCC(N5CCN(C)CC5)CC4)C=C3)=O
Renhedsgrad noter Research
Molekylær formel C29H44N8O3
Til brug med (applikation) Cancer-Kinase/protease
13

EIPA hydrochloride, MedChemExpress

MedChemExpress EIPA (L593754) hydrochloride is an orally active TRPP3 channel inhibitor with an IC50 of 10.5 μM. EIPA hydrochloride also enhances autophagy by inhibiting Na+/H+-exchanger 3 (NHE3). EIPA hydrochloride inhibits macropinocytosis as well. EIPA hydrochloride can be used in the research of inflammation and cancers, such as gastric cancer, colon carcinoma, pancreatic carcinoma.

ENCOMPASS_PREFERRED
Kemisk navn eller materiale EIPA hydrochloride
Formel vægt 336.22
Opløselighedsinformation DMSO : 130 mg/mL (386.65 mM; Need ultrasonic)
Procent renhed 99.92%
Fysisk form Solid
Farve Yellow
Grad Research
Anbefalet opbevaring 4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Molekylvægt (g/mol) 336.22
CAS 1345839-28-2
Synonym L593754 hydrochloride MH 12-43 hydrochloride
Holdbarhed 4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
SMIL O=C(C1=NC(Cl)=C(N(CC)C(C)C)N=C1N)NC(N)=N.Cl
Renhedsgrad noter Research
Molekylær formel C11H19Cl2N7O
Til brug med (applikation) Neuroscience-Neuromodulation
14

Benzamil hydrochloride, MedChemExpress

MedChemExpress Benzamil hydrochloride (Benzylamiloride hydrochloride), an Amiloride analogue, is a Na+/Ca2+ exchanger (NCX) inhibitor (IC50∼100 nM). Benzamil hydrochloride also is a non-selective Deg/epithelial sodium channels (ENaC) blocker, and can potentiate myogenic vasoconstriction. Benzamil hydrochloride inhibits TRPP3-mediated Ca2+-activated currents, with an IC50 of 1.1 μM.

ENCOMPASS_PREFERRED
Kemisk navn eller materiale Benzamil hydrochloride
Sundhedsfare 1 H315∣H319∣H335
Formel vægt 356.21
Opløselighedsinformation DMSO : ≥ 100 mg/mL (280.73 mM) ∣H2O : < 0.1 mg/mL (insoluble)
Procent renhed 99.6%
Fysisk form Solid
Farve Yellow
Grad Research
Anbefalet opbevaring 4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Molekylvægt (g/mol) 356.21
CAS 161804-20-2
Synonym Benzylamiloride hydrochloride
Holdbarhed 4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
SMIL O=C(C1=NC(Cl)=C(N)N=C1N)NC(NCC2=CC=CC=C2)=N.[H]Cl
Renhedsgrad noter Research
Molekylær formel C13H15Cl2N7O
Til brug med (applikation) COVID-19-immunoregulation
15

Amiloride hydrochloride dihydrate, MedChemExpress

MedChemExpress Amiloride hydrochloride dihydrate (MK-870 hydrochloride dihydrate) is an inhibitor of both epithelial sodium channel (ENaC) and urokinase-type plasminogen activator receptor (uTPA). Amiloride hydrochloride dihydrate is a blocker of polycystin-2 (PC2; TRPP2) channel.

ENCOMPASS_PREFERRED