CAS RN 849217-68-1

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XL184, TRC

High-purity organic molecules and analytical standards, strategically delivered worldwide to empower innovation and commercial success.

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XL184, TRC

High-purity organic molecules and analytical standards, strategically delivered worldwide to empower innovation and commercial success.

Pris og tilgængelighed

XL184, TRC

High-purity organic molecules and analytical standards, strategically delivered worldwide to empower innovation and commercial success.

Pris og tilgængelighed

MedChemExpress Cabozantinib is a potent and orally active inhibitor of VEGFR2 and MET, with IC50 values of 0.035, and 1.3 nM, respectively. Cabozantinib displays strong inhibition of KIT, RET, AXL, TIE2, and FLT3 (IC50=4.6, 5.2, 7, 14.3, and 11.3 nM, respectively). Cabozantinib shows antiangiogenic activity. Cabozantinib disrupts tumor vasculature and promotes tumor and endothelial cell apoptosis.

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Tekniske data

Kemisk navn eller materiale	Cabozantinib
Formel vægt	501.51
Opløselighedsinformation	DMSO : ≥ 30 mg/mL (59.82 mM) ∣H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)
Procent renhed	98.0%
Fysisk form	Powder
Farve	Off-White
Grad	Research
Anbefalet opbevaring	4°C, protect from light∣In solvent : -80°C, 6 months∣-20°C, 1 month (protect from light)
Molekylvægt (g/mol)	501.51
CAS	849217-68-1
Synonym	XL184 BMS-907351
Holdbarhed	4°C, protect from light∣In solvent : -80°C, 6 months∣-20°C, 1 month (protect from light)
SMIL	O=C(C1(CC1)C(NC2=CC=C(F)C=C2)=O)NC3=CC=C(C=C3)OC4=C5C=C(OC)C(OC)=CC5=NC=C4
Renhedsgrad noter	Research
Molekylær formel	C₂₈H₂₄FN₃O₅
Til brug med (applikation)	Cancer-Kinase/protease

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