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Cabozantinib, MedChemExpress

Artikelnummer. 16476066
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Artikelnummer. 16476066 Leverandør Medchem Express Leverandørnr. HY13016100mg

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Beskrivelse

MedChemExpress Cabozantinib is a potent and orally active inhibitor of VEGFR2 and MET, with IC50 values of 0.035, and 1.3 nM, respectively. Cabozantinib displays strong inhibition of KIT, RET, AXL, TIE2, and FLT3 (IC50=4.6, 5.2, 7, 14.3, and 11.3 nM, respectively). Cabozantinib shows antiangiogenic activity. Cabozantinib disrupts tumor vasculature and promotes tumor and endothelial cell apoptosis.

Cabozantinib is a potent and orally active inhibitor of VEGFR2 and MET, with IC50 values of 0.035, and 1.3 nM, respectively. Cabozantinib displays strong inhibition of KIT, RET, AXL, TIE2, and FLT3 (IC50=4.6, 5.2, 7, 14.3, and 11.3 nM, respectively). Cabozantinib shows antiangiogenic activity. Cabozantinib disrupts tumor vasculature and promotes tumor and endothelial cell apoptosis.

Tekniske data

Kemisk navn eller materiale Cabozantinib
CAS 849217-68-1
Farve Off-White
Renhedsgrad noter Research
Molekylær formel C28H24FN3O5
Mængde 100 mg
Synonym XL184 BMS-907351
Opløselighedsinformation DMSO : ≥ 30 mg/mL (59.82 mM) ∣H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)
SMIL O=C(C1(CC1)C(NC2=CC=C(F)C=C2)=O)NC3=CC=C(C=C3)OC4=C5C=C(OC)C(OC)=CC5=NC=C4
Molekylvægt (g/mol) 501.51
Formel vægt 501.51
Procent renhed 98.0%
Grad Research
Fysisk form Powder
Til brug med (applikation) Cancer-Kinase/protease
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Research purposes only

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