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CAS RN 475108-18-0

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1

Tivozanib, TRC

CAS: 475108-18-0 Molekylær formel: C22 H19 Cl N4 O5 Molekylvægt (g/mol): 454.86 Synonym: Urea, N-[2-chloro-4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(5-methyl-3-isoxazolyl)-,N-[2-Chloro-4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(5-methyl-3-isoxazolyl)urea,AV 951,KRN 951,Kil 8951,N-[2-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl]-N'-(5-methyl-3-isoxazolyl)urea,Tivozanib IUPAC navn: 1-[2-chloro-4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-3-(5-methyl-1,2-oxazol-3-yl)urea SMIL: COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)on4)c(Cl)c3)c2cc1OC

Molekylvægt (g/mol) 454.86
CAS 475108-18-0
Synonym Urea, N-[2-chloro-4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(5-methyl-3-isoxazolyl)-,N-[2-Chloro-4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(5-methyl-3-isoxazolyl)urea,AV 951,KRN 951,Kil 8951,N-[2-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl]-N'-(5-methyl-3-isoxazolyl)urea,Tivozanib
SMIL COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)on4)c(Cl)c3)c2cc1OC
IUPAC navn 1-[2-chloro-4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-3-(5-methyl-1,2-oxazol-3-yl)urea
Molekylær formel C22 H19 Cl N4 O5
2

Tivozanib, MedChemExpress

MedChemExpress Tivozanib (AV-951; KRN951) is a potent and selective and orally active VEGFR tyrosine kinase inhibitor with IC50是of 0.21, 0.16, 0.24 nM for VEGFR-1, VEGFR-2, VEGFR-3, respectively. Tivozanib inhibits angiogenesis and vascular permeability in tumor tissues and shows antitumor activity. Tivozanib has the potential for the research of metastatic renal cell carcinoma (RCC) .

ENCOMPASS_PREFERRED
Kemisk navn eller materiale Tivozanib
Formel vægt 454.86
Opløselighedsinformation DMSO : 25 mg/mL (54.96 mM; Need ultrasonic)
Procent renhed 99.37%
Fysisk form Solid
Farve Brown
Grad Research
Anbefalet opbevaring Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol) 454.86
CAS 475108-18-0
Synonym AV-951 KRN951
Holdbarhed Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL O=C(NC1=CC=C(C=C1Cl)OC2=CC=NC3=CC(OC)=C(C=C23)OC)NC4=NOC(C)=C4
Renhedsgrad noter Research
Molekylær formel C22H19ClN4O5
Til brug med (applikation) Cancer-Kinase/protease