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Phenoxyforbindelser

Organiske forbindelser, der har en eller flere phenylgrupper, der er bundet til en oxygen med en radikalelektron; omfatter forbindelser med yderligere substitutioner.

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1 – 4 af 4 Resultater
1

R406 free base, MedChemExpress

MedChemExpress R406 free base is an orally available and competitive Syk/FLT3 inhibitor for ATP binding with a Ki of 30 nM, potently inhibits Syk kinase activity in vitro with an IC50 of 41 nM, measured at an ATP concentration corresponding to its Km value. R406 free base reduces immune complex-mediated inflammation. R406 free base also inhibits Lyn (IC50=63 nM) and Lck (IC50=37 nM).

ENCOMPASS_PREFERRED
Kemisk navn eller materiale R406 free base
Sundhedsfare 1 H302∣H315∣H319∣H335
Formel vægt 470.45
Opløselighedsinformation DMSO : ≥ 10 mg/mL (21.26 mM)
Procent renhed 98.15%
Fysisk form Solid
Farve Light Yellow
Grad Research
Anbefalet opbevaring Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol) 470.45
CAS 841290-80-0
Holdbarhed Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL COC1=CC(NC2=NC(NC3=NC(N4)=C(C=C3)OC(C)(C)C4=O)=C(C=N2)F)=CC(OC)=C1OC
Renhedsgrad noter Research
Molekylær formel C22H23FN6O5
Til brug med (applikation) COVID-19-immunoregulation
2

YHO-13351 free base, MedChemExpress

MedChemExpress YHO-13351 free base is the prodrug of YHO-13177, which is a potent and specific inhibitor of BCRP.

ENCOMPASS_PREFERRED
Kemisk navn eller materiale YHO-13351 free base
Formel vægt 483.62
Opløselighedsinformation DMSO : 100 mg/mL (206.77 mM; Need ultrasonic)
Procent renhed 99.0%
Fysisk form Solid
Farve Orange
Grad Research
Anbefalet opbevaring Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol) 483.62
CAS 912288-64-3
Holdbarhed Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL N#C/C(C1=CC=C(OC)C(OC)=C1)=C\C2=CC=C(N3CCC(OC(CN(CC)CC)=O)CC3)S2
Renhedsgrad noter Research
Molekylær formel C26H33N3O4S
Til brug med (applikation) Cancer-programmed cell death
3

Genz-123346 free base, MedChemExpress

MedChemExpress Genz-123346 (free base) is an inhibitor of GL1 synthase that blocks the conversion of ceramide to GL1; inhibits GM1 with IC50 value of 14 nM.

ENCOMPASS_PREFERRED
Kemisk navn eller materiale Genz-123346 free base
Formel vægt 418.57
Opløselighedsinformation DMSO : ≥ 100 mg/mL (238.91 mM)
Procent renhed 98.0%
Fysisk form Solid
Farve White
Grad Research
Anbefalet opbevaring Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol) 418.57
CAS 491833-30-8
Holdbarhed Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL CCCCCCCCC(N[C@H](CN1CCCC1)[C@@H](C2=CC=C(OCCO3)C3=C2)O)=O
Renhedsgrad noter Research
Molekylær formel C24H38N2O4
Til brug med (applikation) Cancer-Kinase/protease
4

Zatebradine, MedChemExpress

MedChemExpress Zatebradine (UL-FS-49 (free base); UL-FS-49CL (free base)) is a potent inhibitor of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels with an IC50 value of 1.96 μM. Zatebradine blocks the slow inward current through human HCN1, HCN2, HCN3 and HCN4 channels, with IC50 values of 1.83 μM, 2.21 μM, 1.90 μM and 1.88 μM, respectively.

ENCOMPASS_PREFERRED
Kemisk navn eller materiale Zatebradine
Formel vægt 456.57
Opløselighedsinformation Ethanol : 100 mg/mL (219.02 mM; Need ultrasonic) ∣DMSO : ≥ 50 mg/mL (109.51 mM)
Procent renhed 99.0%
Fysisk form Oil
Farve Brown
Grad Research
Anbefalet opbevaring Pure form -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol) 456.57
CAS 85175-67-3
Synonym UL-FS-49 free baseUL-FS-49CL free base
Holdbarhed Pure form -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL O=C1N(CCCN(CCC2=CC=C(OC)C(OC)=C2)C)CCC3=CC(OC)=C(OC)C=C3C1
Renhedsgrad noter Research
Molekylær formel C26H36N2O5
Til brug med (applikation) COVID-19-immunoregulation