CAS RN 2230821-27-7

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Tocris Bioscience™ Gefitinib-based PROTAC™ 3

Potent EGFR PROTAC™

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Gefitinib-based PROTAC 3, MedChemExpress

MedChemExpress Gefitinib-based PROTAC 3, conjugating an EGFR binding element to a von Hippel-Lindau ligand via a linker, induces EGFR degradation with DC50s of 11.7 nM and 22.3 nM in HCC827(exon 19 del) and H3255 (L858R mutantion) cells, respectively.

Pris og tilgængelighed
Tekniske data

Kemisk navn eller materiale	Gefitinib-based PROTAC 3
Formel vægt	934.51
Opløselighedsinformation	DMSO : ≥ 60 mg/mL (64.20 mM)
Procent renhed	98.24%
Fysisk form	Solid
Farve	White
Grad	Research
Anbefalet opbevaring	4°C, sealed storage, away from moisture and light∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture and light)
Molekylvægt (g/mol)	934.51
CAS	2230821-27-7
Holdbarhed	4°C, sealed storage, away from moisture and light∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture and light)
SMIL	O=C([C@H]1N(C([C@@H](NC(CCOCCOCCCCCOC2=CC3=C(NC4=CC=C(F)C(Cl)=C4)N=CN=C3C=C2OC)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC5=CC=C(C6=C(C)N=CS6)C=C5
Renhedsgrad noter	Research
Molekylær formel	C₄₇H₅₇ClFN₇O₈S
Til brug med (applikation)	Cancer-Kinase/protease

CAS RN 2230821-27-7

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Tocris Bioscience™ Gefitinib-based PROTAC™ 3 Greener Choice ProductThis product offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”Learn More About the Greener Choice Program

Tocris Bioscience™ Gefitinib-based PROTAC™ 3