CAS RN 1392429-79-6

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BI-882370, MedChemExpress

MedChemExpress BI-882370 is a potent and selective RAF kinase inhibitor that binds to the ATP binding site of the kinase positioned in the DFG-out (inactive) conformation of the BRAF kinase. BI-882370 (BI 882370) inhibits the oncogenic BRAFV600E-mutant, the WT BRAF and CRAF kinases with IC50s of 0.4, 0.8, and 0.6 nM, respectively. BI-882370 also inhibits SRC family kinases.

Pris og tilgængelighed
Tekniske data

Kemisk navn eller materiale	BI-882370
Formel vægt	569.67
Opløselighedsinformation	DMSO : 5 mg/mL (8.78 mM; ultrasonic and warming and heat to 60°C) ∣H2O : < 0.1 mg/mL (insoluble)
Procent renhed	95.02%
Fysisk form	Solid
Farve	Khaki
Grad	Research
Anbefalet opbevaring	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol)	569.67
CAS	1392429-79-6
Holdbarhed	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL	CCCS(=O)(NC1=CC=C(F)C(N2C=C(C3=CN=CN=C3)C4=NC(N(C5CCN(CC)CC5)C)=CC=C42)=C1F)=O
Renhedsgrad noter	Research
Molekylær formel	C₂₈H₃₃F₂N₇O₂S
Til brug med (applikation)	Cancer-Kinase/protease

CAS RN 1392429-79-6

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