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BI-882370, MedChemExpress

Artikelnummer. 16465116
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Artikelnummer. 16465116 Leverandør Medchem Express Leverandørnr. HY107779

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Beskrivelse

MedChemExpress BI-882370 is a potent and selective RAF kinase inhibitor that binds to the ATP binding site of the kinase positioned in the DFG-out (inactive) conformation of the BRAF kinase. BI-882370 (BI 882370) inhibits the oncogenic BRAFV600E-mutant, the WT BRAF and CRAF kinases with IC50s of 0.4, 0.8, and 0.6 nM, respectively. BI-882370 also inhibits SRC family kinases.

BI-882370 is a potent and selective RAF kinase inhibitor that binds to the ATP binding site of the kinase positioned in the DFG-out (inactive) conformation of the BRAF kinase. BI-882370 (BI 882370) inhibits the oncogenic BRAFV600E-mutant, the WT BRAF and CRAF kinases with IC50s of 0.4, 0.8, and 0.6 nM, respectively. BI-882370 also inhibits SRC family kinases.

Tekniske data

Kemisk navn eller materiale BI-882370
CAS 1392429-79-6
Farve Khaki
Renhedsgrad noter Research
Molekylær formel C28H33F2N7O2S
Mængde 100 mg
Opløselighedsinformation DMSO : 5 mg/mL (8.78 mM; ultrasonic and warming and heat to 60°C) ∣H2O : < 0.1 mg/mL (insoluble)
SMIL CCCS(=O)(NC1=CC=C(F)C(N2C=C(C3=CN=CN=C3)C4=NC(N(C5CCN(CC)CC5)C)=CC=C42)=C1F)=O
Molekylvægt (g/mol) 569.67
Formel vægt 569.67
Procent renhed 95.02%
Grad Research
Fysisk form Solid
Til brug med (applikation) Cancer-Kinase/protease
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Research purposes only

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