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CAS RN 1223405-08-0

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1

Larotrectinib Sulfate, TRC

CAS: 1223405-08-0 Molekylær formel: C21H22F2N6O2 . (H2O4S) Molekylvægt (g/mol): 526.5 Synonym: LOXO 101 sulfate,(3S)-N-[5-[(2R)-2-(2,5-Difluorophenyl)-1-pyrrolidinyl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxy-1-pyrrolidinecarboxamide Sulfate SMIL: O[C@H]1CCN(C1)C(=O)Nc2cnn3ccc(nc23)N4CCC[C@@H]4c5cc(F)ccc5F.OS(=O)(=O)O

Molekylvægt (g/mol) 526.5
CAS 1223405-08-0
Synonym LOXO 101 sulfate,(3S)-N-[5-[(2R)-2-(2,5-Difluorophenyl)-1-pyrrolidinyl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxy-1-pyrrolidinecarboxamide Sulfate
SMIL O[C@H]1CCN(C1)C(=O)Nc2cnn3ccc(nc23)N4CCC[C@@H]4c5cc(F)ccc5F.OS(=O)(=O)O
Molekylær formel C21H22F2N6O2 . (H2O4S)
2

Larotrectinib sulfate, MedChemExpress

MedChemExpress Larotrectinib sulfate (LOXO-101 sulfate; ARRY-470 sulfate) is an ATP-competitive oral, selective inhibitor of the tropomyosin-related kinase (TRK) family receptors, with low nanomolar 50% inhibitory concentrations against all three isoforms (TRKA, B, and C).

ENCOMPASS_PREFERRED
Kemisk navn eller materiale Larotrectinib sulfate
Formel vægt 526.51
Opløselighedsinformation DMSO : 50 mg/mL (94.96 mM; Need ultrasonic) ∣H2O : 2 mg/mL (3.80 mM; ultrasonic and adjust pH to 2 with 1M HCl)
Procent renhed 98.69%
Fysisk form Solid
Farve Light Yellow
Grad Research
Anbefalet opbevaring 4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Molekylvægt (g/mol) 526.51
CAS 1223405-08-0
Synonym LOXO-101 sulfateARRY-470 sulfate
Holdbarhed 4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
SMIL O=S(O)(O)=O.O=C(N1CC[C@H](O)C1)NC2=C3N=C(N4[C@@H](C5=CC(F)=CC=C5F)CCC4)C=CN3N=C2
Renhedsgrad noter Research
Molekylær formel C21H24F2N6O6S
Til brug med (applikation) Cancer-Kinase/protease