CAS RN 118414-82-7

IUPAC Navn: 3-[3-(butylsulfanyl)-1-[(4-chlorophenyl)methyl]-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid

Synonymer: 3-[3-(butylsulfanyl)-1-[(4-chlorophenyl)methyl]-5-isopropylindol-2-yl]-2,2-dimethylpropanoic acid

Molekylvægt (g/mol): 472.08

Molekylformel: C27H34ClNO2S

InChi Key: VFMGWQLOCZBFCK-UHFFFAOYSA-N

SMILES: CCCCSC1=C(CC(C)(C)C(O)=O)N(CC2=CC=C(Cl)C=C2)C2=CC=C(C=C12)C(C)C

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Tocris Bioscience™ MK 886

Inhibitor of 5-lipoxygenase-activating protein (FLAP)

Pris og tilgængelighed

MK-886, TRC

CAS: 118414-82-7 Molekylær formel: C27H34ClNO2S Molekylvægt (g/mol): 472.08 Synonym: MK-886,L 663536 SMIL: CC(C)c1ccc2c(c1)c(SC(C)(C)C)c(CC(C)(C)C(=O)O)n2Cc3ccc(Cl)cc3

Pris og tilgængelighed
Tekniske data

Molekylvægt (g/mol)	472.08
CAS	118414-82-7
Synonym	MK-886,L 663536
SMIL	CC(C)c1ccc2c(c1)c(SC(C)(C)C)c(CC(C)(C)C(=O)O)n2Cc3ccc(Cl)cc3
Molekylær formel	C27H34ClNO2S

MedChemExpress MK-886 (L 663536) is a potent, cell-permeable and orally active FLAP (IC50 of 30 nM) and leukotriene biosynthesis (IC50s of 3 nM and 1.1 μM in intact leukocytes and human whole blood, respectively) inhibitor. MK-886 is also a non-competitive PPARα antagonist and can induce apoptosis.

Pris og tilgængelighed
Tekniske data

Kemisk navn eller materiale	MK-886
Sundhedsfare 1	H302∣H315∣H319∣H335
Formel vægt	472.08
Opløselighedsinformation	DMSO : 75 mg/mL (158.87 mM; Need ultrasonic)
Procent renhed	99.11%
Fysisk form	Solid
Farve	White
Grad	Research
Anbefalet opbevaring	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol)	472.08
CAS	118414-82-7
Synonym	L 663536
Holdbarhed	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL	CC(C)C1=CC=C(N(CC2=CC=C(Cl)C=C2)C(CC(C)(C(O)=O)C)=C3SC(C)(C)C)C3=C1
Renhedsgrad noter	Research
Molekylær formel	C₂₇H₃₄ClNO₂S
Til brug med (applikation)	Cancer-programmed cell death

CAS RN 118414-82-7

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