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N-Acetyl-D-mannosamine, 98%, Thermo Scientific Chemicals

N-Acetyl-D-mannosamine (ManNAc), CAS # 7772-94-3, is a monosaccharide sialic acid precursor.

379.00 DKK - 1240.00 DKK

Chemical Identifiers

CAS 7772-94-3
Molecular Formula C8H17NO7
Molecular Weight (g/mol) 239.22
MDL Number MFCD00149493,MFCD00046758,MFCD00149493,MFCD00069808
InChI Key VVQPUTSNIMAJPT-UHFFFAOYNA-N
Synonym n-acetylmannosamine
PubChem CID 11908605
IUPAC Name N-[(2R,3S,4S,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide
SMILES O.CC(=O)NC1C(O)OC(CO)C(O)C1O
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Description

Description

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • N-Acetyl-D-mannosamine (ManNAc) is a precursor used to synthesize N-acetylneuraminic acid, the most common physiologic sialic acid present in humans and other mammals
  • Sialic acids are terminal sugars on glycoconjugates that can modify biochemistry of glycoproteins and lipids, mediate cellular adhesion, and act as immune regulators
  • Defects in sialic acid biosynthesis are associated with a number of pathologies
  • Sialic acids are often found at increased expression levels on tumor cell surfaces

Applications

  • As a sialic acid precursor, N-Acetyl-D-mannosamine can be used in many glycoengineering applications, such as modifying immune cell activity, imaging glycans, or blocking pathogen binding
  • N-Acetyl-D-mannosamine hasbeen used in preclinical laboratory studies as a treatment for hereditary inclusion body myopathy, a progressive neuromuscular disease via increased sialylation of podocalyxin
  • N-Acetyl-D-mannosamine has been used in laboratory studies to induce IgG sialylation and prevent obesity-induced hypertension in mice following high-fat diet
Specifications
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Safety and Handling

Safety and Handling

GHS H Statement:
Causes skin irritation.
Causes serious eye irritation.
May cause respiratory irritation.

GHS P Statement:
Avoid breathing dust/fume/gas/mist/vapors/spray.
IF ON SKIN: Wash with plenty of soap and water.
Wear protective gloves/protective clothing/eye protection/face protection.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

WARNING: The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling and use. It is not to be considered as either a warranty or quality specification.

Product Identifier
  • N-Acetyl-D-mannosamine

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