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Cytarabine, 98%
Cytarabine, CAS # 147-94-4, is an inhibitor of DNA synthesis that is used as an anticancer and antiviral agent. | CAS: 147-94-4 | C9H13N3O5 | 243.22 g/mol
302.00 DKK - 4600.00 DKK
Chemical Identifiers
| CAS | 147-94-4 |
|---|---|
| Molecular Formula | C9H13N3O5 |
| Molecular Weight (g/mol) | 243.22 |
| InChI Key | UHDGCWIWMRVCDJ-CCXZUQQUSA-N |
| Synonym | cytarabine, cytosine arabinoside, ara-c, arabinocytidine, cytosar, arabinosylcytosine, aracytidine, cytarabin, cytarabinoside, tarabine |
| PubChem CID | 6253 |
| ChEBI | CHEBI:28680 |
| IUPAC Name | 4-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one |
| SMILES | C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)O |
| Product Code | Brand | Quantity | Packaging | Price | Quantity & Availability | ||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Packaging | Price | Quantity & Availability | ||||
|
15244774
|
Thermo Scientific Acros
449561000 |
100 mg | Glass bottle |
302.00 DKK
100mg |
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|
15224774
|
Thermo Scientific Acros
449560010 |
1 g | Glass bottle |
1365.00 DKK
1g |
Please sign in to purchase this item. Need a web account? Register with us today! | ||||
|
15234774
|
Thermo Scientific Acros
449560050 |
5 g | Glass bottle |
4600.00 DKK
5g |
Please sign in to purchase this item. Need a web account? Register with us today! | ||||
Description
This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
- Cytarabine is a nucleoside analog that acts as an antileukemic agent
- Cytarabine becomes cytotoxic following conversion to its triphosphorylated form, which can be incorporated into DNA primers by DNA polymerase alpha
- Can induce S phase cell cycle arrest and apoptosis in leukemic and neuronal cells
Applications
- Has been used to study chemotherapeutic regimens in laboratory studies of leukemia
- Useful for laboratory studies of cytarabine resistance mechanisms
- At nanomolar concentrations, cytarabine has been seen to induce mitochondrial apoptosis in leukemic cells through upregulation of multiple Bcl-2 family members
- It can induce neuronal cell death via inducing Îł-H2AX phosphorylation in histones, in the absence of double-stranded DNA breaks
Chemical Identifiers
| 147-94-4 | |
| 243.22 | |
| cytarabine, cytosine arabinoside, ara-c, arabinocytidine, cytosar, arabinosylcytosine, aracytidine, cytarabin, cytarabinoside, tarabine | |
| CHEBI:28680 | |
| C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)O |
| C9H13N3O5 | |
| UHDGCWIWMRVCDJ-CCXZUQQUSA-N | |
| 6253 | |
| 4-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one |
Specifications
| 147-94-4 | |
| 97.5% min. (HPLC) | |
| 152781 | |
| Solubility in water: soluble. Other solubilities: soluble in dmso, ethanol | |
| C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)O | |
| 243.22 | |
| CHEBI:28680 | |
| 98% |
| 220.0°C | |
| C9H13N3O5 | |
| cytarabine, cytosine arabinoside, ara-c, arabinocytidine, cytosar, arabinosylcytosine, aracytidine, cytarabin, cytarabinoside, tarabine | |
| UHDGCWIWMRVCDJ-CCXZUQQUSA-N | |
| 4-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one | |
| 6253 | |
| 243.22 | |
| Cytarabine |
Safety and Handling
Causes serious eye irritation, Suspected of causing genetic defects, Suspected of damaging fertility or the unborn child, May cause an allergic skin reaction
Serious eye damage/eye irritation (category 2), Germ cell mutagenicity (category 2), Reproductive toxicity (category 2), Skin sensitisation (category 1)
missing translation for 'einecsNumber' : 205-705-9
Product Identifier
Signal Word
Hazard Category
Hazard Statement
Precautionary Statement
- Cytosine beta-D-arabinofuranoside
Signal Word
- Warning
Hazard Category
- Serious eye damage/eye irritation Category 2
- Reproductive toxicity Category 2
- Respiratory sensitiser Category 1
Hazard Statement
- H317-May cause an allergic skin reaction.
- H361d-Suspected of damaging the unborn child.
- H319-Causes serious eye irritation.
Precautionary Statement
- P201-Obtain special instructions before use.
- P280-Wear protective gloves/protective clothing/eye protection/face protection.
- P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
RUO – Research Use Only
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Product Title
Cytarabine, 98%