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Pyrrolidines

Organic heterocyclic compounds that consist of a five-membered ring with four carbon atoms and one nitrogen atom that form a cyclic secondary amine.
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Ro 31-8220 mesylate, MedChemExpress

MedChemExpress Ro 31-8220 mesylate is a potent PKC inhibitor, with IC50s of 5, 24, 14, 27, 24 and 23 nM for PKCα, PKCβI, PKCβII, PKCγ, PKCε and rat brain PKC, respectively. Ro 31-8220 also significantly inhibits MAPKAP-K1b, MSK1, S6K1 and GSK3β (IC50s, 3, 8, 15, and 38 nM, respectively), with no effect on MKK3, MKK4, MKK6 and MKK7.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 553.65
Color Orange
Physical Form Solid
Chemical Name or Material Ro 31-8220 mesylate
Grade Research
SMILES NC(SCCCN1C=C(C2=C(C3=CN(C)C4=C3C=CC=C4)C(NC2=O)=O)C5=C1C=CC=C5)=N.CS(=O)(O)=O
For Use With (Application) Cancer-Kinase/protease
Percent Purity 98.0%
CAS 138489-18-6
Solubility Information DMSO : 35.71 mg/mL (64.50 mM; Need ultrasonic) ∣H2O : < 0.1 mg/mL (insoluble)
Synonym Ro 31-8220 methanesulfonate Bisindolylmaleimide IX mesylate
Purity Grade Notes Research
Recommended Storage 4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Shelf Life 4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Molecular Formula C26H27N5O5S2
Formula Weight 553.65

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