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Ro 31-8220 mesylate, MedChemExpress

Artikelnummer. 16415898
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16415898 10 mg
16412047 50 mg
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Artikelnummer. 16415898 Leverandør Medchem Express Leverandørnr. HY13866

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Beskrivelse

MedChemExpress Ro 31-8220 mesylate is a potent PKC inhibitor, with IC50s of 5, 24, 14, 27, 24 and 23 nM for PKCα, PKCβI, PKCβII, PKCγ, PKCε and rat brain PKC, respectively. Ro 31-8220 also significantly inhibits MAPKAP-K1b, MSK1, S6K1 and GSK3β (IC50s, 3, 8, 15, and 38 nM, respectively), with no effect on MKK3, MKK4, MKK6 and MKK7.

Ro 31-8220 mesylate is a potent PKC inhibitor, with IC50s of 5, 24, 14, 27, 24 and 23 nM for PKCα, PKCβI, PKCβII, PKCγ, PKCε and rat brain PKC, respectively. Ro 31-8220 also significantly inhibits MAPKAP-K1b, MSK1, S6K1 and GSK3β (IC50s, 3, 8, 15, and 38 nM, respectively), with no effect on MKK3, MKK4, MKK6 and MKK7.

Tekniske data

Kemisk navn eller materiale Ro 31-8220 mesylate
CAS 138489-18-6
Farve Orange
Renhedsgrad noter Research
Molekylær formel C26H27N5O5S2
Mængde 10 mg
Synonym Ro 31-8220 methanesulfonate Bisindolylmaleimide IX mesylate
Opløselighedsinformation DMSO : 35.71 mg/mL (64.50 mM; Need ultrasonic) ∣H2O : < 0.1 mg/mL (insoluble)
SMIL NC(SCCCN1C=C(C2=C(C3=CN(C)C4=C3C=CC=C4)C(NC2=O)=O)C5=C1C=CC=C5)=N.CS(=O)(O)=O
Molekylvægt (g/mol) 553.65
Formel vægt 553.65
Procent renhed 98.0%
Grad Research
Fysisk form Solid
Til brug med (applikation) Cancer-Kinase/protease
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Research purposes only

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