CAS RN 879487-87-3

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R-268712, MedChemExpress

MedChemExpress R-268712 is an orally active and selective ALK-5 inhibitor, with an IC50 of 2.5 nM. R-268712 inhibits the phosphorylation of Smad3 in a dose-dependent manner with an IC50 of 10.4 nM. R-268712 suppresses glomerulonephritis as well as glomerulosclerosis by inhibiting TGF-β signaling, which can be used in studies of renal fibrosis and cancer.

Pris og tilgængelighed
Tekniske data

Kemisk navn eller materiale	R-268712
Sundhedsfare 1	H302∣H315∣H319∣H335
Formel vægt	363.39
Opløselighedsinformation	DMSO : 125 mg/mL (343.98 mM; Need ultrasonic)
Procent renhed	98.0%
Fysisk form	Solid
Farve	Light Yellow
Grad	Research
Anbefalet opbevaring	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol)	363.39
CAS	879487-87-3
Holdbarhed	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL	FC1=C(C2=CN(CCO)N=C2)C=C(C3=CNN=C3C4=CC=CC(C)=N4)C=C1
Renhedsgrad noter	Research
Molekylær formel	C₂₀H₁₈FN₅O
Til brug med (applikation)	Cancer-Kinase/protease

CAS RN 879487-87-3

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