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R-268712, MedChemExpress

Artikelnummer. 16496036
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Pakningsstørrelse:
50mg
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16435448 10 mg -
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Artikelnummer. 16496036 Leverandør Medchem Express Leverandørnr. HY12953

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Beskrivelse

MedChemExpress R-268712 is an orally active and selective ALK-5 inhibitor, with an IC50 of 2.5 nM. R-268712 inhibits the phosphorylation of Smad3 in a dose-dependent manner with an IC50 of 10.4 nM. R-268712 suppresses glomerulonephritis as well as glomerulosclerosis by inhibiting TGF-β signaling, which can be used in studies of renal fibrosis and cancer.

R-268712 is an orally active and selective ALK-5 inhibitor, with an IC50 of 2.5 nM. R-268712 inhibits the phosphorylation of Smad3 in a dose-dependent manner with an IC50 of 10.4 nM. R-268712 suppresses glomerulonephritis as well as glomerulosclerosis by inhibiting TGF-β signaling, which can be used in studies of renal fibrosis and cancer.

Tekniske data

Kemisk navn eller materiale R-268712
CAS 879487-87-3
Farve Light Yellow
Renhedsgrad noter Research
Molekylær formel C20H18FN5O
Mængde 100 mg
Opløselighedsinformation DMSO : 125 mg/mL (343.98 mM; Need ultrasonic)
SMIL FC1=C(C2=CN(CCO)N=C2)C=C(C3=CNN=C3C4=CC=CC(C)=N4)C=C1
Molekylvægt (g/mol) 363.39
Formel vægt 363.39
Procent renhed 98.0%
Grad Research
Fysisk form Solid
Til brug med (applikation) Cancer-Kinase/protease
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Research purposes only

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