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CAS RN 75747-14-7

H3CO(R)(R)H3CNHH2CONHO(R)OCH3(R)ONH2O(R)CH3(S)OHCH3H3CO(Z)(E)(E)

CAS RN 75747-14-7

IUPAC Navn: (4Z,6E,8R,9R,10E,12R,13S,14R,16R)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-19-[(prop-2-en-1-yl)amino]-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
Synonymer: tanespimycin
Molekylvægt (g/mol): 585.7
Molekylformel: C31H43N3O8
InChi Key: AYUNIORJHRXIBJ-CQFHKJEWSA-N
SMILES: CO[C@@H]1C[C@H](C)CC2=C(NCC=C)C(=O)C=C(NC(=O)\C(C)=C/C=C/[C@@H](OC)[C@H](OC(N)=O)\C(C)=C\[C@@H](C)[C@@H]1O)C2=O
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1 – 4 af 4 Resultater
1

17-(Allylamino)-17-demethoxygeldanamycin, 99%

CAS: 75747-14-7 Molekylær formel: C31H43N3O8 Molekylvægt (g/mol): 585.698 MDL nummer: MFCD04973892 InChI nøgle: AYUNIORJHRXIBJ-MKJFUHJFSA-N Synonym: 17-aag PubChem CID: 133688938 IUPAC navn: [(3S,5R,6S,7R,8Z,11R,14E)-6-hydroxy-5,11-dimethoxy-3,7,9,15-tetramethyl-16,20,22-tri oxo-21-(prop-2-enylamino)-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamat SMIL: CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCC=C)C)OC)OC(=O)N)C)C)O)OC

MDL nummer MFCD04973892
PubChem CID 133688938
Molekylvægt (g/mol) 585.698
CAS 75747-14-7
Synonym 17-aag
SMIL CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCC=C)C)OC)OC(=O)N)C)C)O)OC
IUPAC navn [(3S,5R,6S,7R,8Z,11R,14E)-6-hydroxy-5,11-dimethoxy-3,7,9,15-tetramethyl-16,20,22-tri oxo-21-(prop-2-enylamino)-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamat
InChI nøgle AYUNIORJHRXIBJ-MKJFUHJFSA-N
Molekylær formel C31H43N3O8
2

Tocris Bioscience™ 17-AAG
GREENER_CHOICE

3

Melford 17-AAG

17-AAG (17-Allylamino-17-demethoxygeldanamycin) er et syntetisk derivat af geldanamycin. Ligesom geldanamycin er 17-AAG anerkendt for sin rolle som en inhibitor af varmechokprotein 90 (Hsp90), en molekylær chaperon involveret i proteinfoldning og stabilisering.

CAS 75747-14-7
Molekylær formel C31H43N3O8
4

Tanespimycin, MedChemExpress

MedChemExpress Tanespimycin (17-AAG) is a potent HSP90 inhibitor with an IC50 of 5 nM, having a 100-fold higher binding affinity for tumour cell derived HSP90 than normal cell derived HSP90. Tanespimycin depletes cellular STK38/NDR1 and reduces STK38 kinase activity. Tanespimycin also downregulates the stk38 gene expression.

ENCOMPASS_PREFERRED
Kemisk navn eller materiale Tanespimycin
Sundhedsfare 1 H302∣H315∣H319∣H335
Formel vægt 585.69
Opløselighedsinformation DMSO : 50 mg/mL (85.37 mM; Need ultrasonic)
Procent renhed 97.41%
Fysisk form Powder
Farve Pale Purple
Grad Research
Anbefalet opbevaring 4°C, protect from light∣In solvent : -80°C, 6 months∣-20°C, 1 month (protect from light)
Molekylvægt (g/mol) 585.69
CAS 75747-14-7
Synonym 17-AAG NSC 330507 CP 127374
Holdbarhed 4°C, protect from light∣In solvent : -80°C, 6 months∣-20°C, 1 month (protect from light)
SMIL O=C(C(NC(/C(C)=C/C=C\[C@H](OC)[C@H](/C(C)=C/[C@@H]([C@H]([C@H](C[C@@H](C1)C)OC)O)C)OC(N)=O)=O)=CC2=O)C1=C2NCC=C
Renhedsgrad noter Research
Molekylær formel C31H43N3O8
Til brug med (applikation) Cancer-Kinase/protease