CAS RN 686770-61-6
CAS RN 686770-61-6
IUPAC Navn:
N-(6-methyl-1,3-benzothiazol-2-yl)-2-({4-oxo-3-phenyl-3H,4H,6H,7H-thieno[3,2-d]pyrimidin-2-yl}sulfanyl)acetamide
Synonymer:
N-(6-methyl-1,3-benzothiazol-2-yl)-2-({4-oxo-3-phenyl-6H,7H-thieno[3,2-d]pyrimidin-2-yl}sulfanyl)acetamide
Molekylvægt (g/mol):
466.59
Molekylformel:
C22H18N4O2S3
InChi Key:
WRKPZSMRWPJJDH-UHFFFAOYSA-N
SMILES:
CC1=CC=C2N=C(NC(=O)CSC3=NC4=C(SCC4)C(=O)N3C3=CC=CC=C3)SC2=C1
1
–
3
af
3
Resultater
1
Tocris Bioscience™ IWP 2
CAS: 686770-61-6 Molekylær formel: C22H18N4O2S3
2
3
IWP-2, MedChemExpress
MedChemExpress IWP-2 is an inhibitor of Wnt processing and secretion with an IC50 of 27 nM. IWP-2 targets the membrane-bound O-acyltransferase porcupine (Porcn) and thus preventing a crucial Wnt ligand palmitoylation. IWP-2 is also an ATP-competitive CK1δ inhibitor with an IC50 of 40 nM for the gatekeeper mutant M82FCK1δ.
