CAS RN 2035814-50-5

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JNJ-61432059, MedChemExpress

MedChemExpress JNJ-61432059 is an oral active and selective negative modulator of AMPAR associated with trans-membrane AMPAR regulatory protein (TARP) γ-8, with a pIC50 of 9.7 for GluA1/γ-8. Exhibits time- and dose-dependent AMPAR/γ-8 receptor occupancy in mouse hippocampus, resulting in robust seizure protection in corneal kindling and pentylenetetrazole (PTZ) anticonvulsant models.

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Tekniske data

Kemisk navn eller materiale	JNJ-61432059
Formel vægt	443.47
Opløselighedsinformation	DMSO : 50 mg/mL (112.75 mM; Need ultrasonic)
Procent renhed	98.75%
Fysisk form	Solid
Farve	Off-White
Grad	Research
Anbefalet opbevaring	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol)	443.47
CAS	2035814-50-5
Holdbarhed	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL	OC1CCN(C2=NC=CC3=C(C4=CC=C(NC(C5)=O)C5=C4)C(C6=CC=C(F)C=C6)=NN32)CC1
Renhedsgrad noter	Research
Molekylær formel	C₂₅H₂₂FN₅O₂
Til brug med (applikation)	Neuroscience-Neuromodulation

CAS RN 2035814-50-5

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