CAS RN 1562338-42-4

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MedChemExpress Branaplam (LMI070; NVS-SM1) is a highly potent, selective and orally active survival motor neuron-2 (SMN2) splicing modulator with an EC50 of 20 nM for SMN. Branaplam inhibits human-ether-a-go-go-related gene (hERG) with an IC50 of 6.3 μM. Branaplam elevates full-length SMN protein and extends survival in a severe spinal muscular atrophy (SMA) mouse model.

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Tekniske data

Kemisk navn eller materiale	Branaplam
Formel vægt	393.48
Opløselighedsinformation	DMSO : 5 mg/mL (12.71 mM; ultrasonic and warming and heat to 80°C)
Procent renhed	95.62%
Fysisk form	Powder
Farve	Yellow
Grad	Research
Anbefalet opbevaring	4°C, sealed storage, away from moisture and light∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture and light)
Molekylvægt (g/mol)	393.48
CAS	1562338-42-4
Synonym	LMI070 NVS-SM1
Holdbarhed	4°C, sealed storage, away from moisture and light∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture and light)
SMIL	OC1=CC(C2=CNN=C2)=CC=C1C3=CC=C(OC4CC(C)(C)NC(C)(C)C4)N=N3
Renhedsgrad noter	Research
Molekylær formel	C₂₂H₂₇N₅O₂
Til brug med (applikation)	Cancer-programmed cell death

CAS RN 1562338-42-4

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