CAS RN 1290543-63-3

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Nirogacestat, MedChemExpress

MedChemExpress Nirogacestat (PF-3084014) is a reversible, orally bioavailable, noncompetitive, and selective γ-secretase inhibitor with an IC50 of 6.2 nM. Inhibition of Notch signaling by Nirogacestat while minimizing gastrointestinal toxicity presents a promising approach for research of Notch receptor-dependent cancers.

Pris og tilgængelighed
Tekniske data

Kemisk navn eller materiale	Nirogacestat
Sundhedsfare 1	H315∣H319∣H335
Formel vægt	489.64
Opløselighedsinformation	DMSO : 28.57 mg/mL (58.35 mM; Need ultrasonic) ∣H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)
Procent renhed	97.5%
Fysisk form	Solid
Farve	White
Grad	Research
Anbefalet opbevaring	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol)	489.64
CAS	1290543-63-3
Synonym	PF-3084014 PF-03084014
Holdbarhed	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL	FC1=C2C(CC[C@H](N[C@@H](CCC)C(NC3=CN(C(C)(C)CNCC(C)(C)C)C=N3)=O)C2)=CC(F)=C1
Renhedsgrad noter	Research
Molekylær formel	C₂₇H₄₁F₂N₅O
Til brug med (applikation)	Cancer-programmed cell death

CAS RN 1290543-63-3

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