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Beskrivelse
Acts by plugging up the channels and limiting the entry of calcium into both smooth muscle cells of arteriolar walls and the cardiac muscle cells at higher doses.
- Blocks L-type Ca2+ channels in smooth and cardiac muscle
- Induces apoptosis of human primary and metastatic colon adenocarcinoma cells in vitro
- Drug resistance reversal agent acting on Pgp, e.g. decrease renal tubule elimination of digoxin
- Increases basal ATPase activity of Pgp
- Substrate of Cyp3A4 and CYP2C6
Tekniske data
Tekniske data
| CAS | 152-11-4 |
| Smeltepunkt | 140°C to 150°C (literature) |
| Molekylær formel | C27H39ClN2O4 |
| Mængde | 1 g |
| Synonym | verapamil hydrochloride, verapamil hcl, manidon, calcan hydrochloride, cardibeltin, cardiabeltin, cardioprotect, veroptinstada, calaptin, caveril |
| Opløselighedsinformation | Soluble in water (7g/100mL); sparingly soluble in chloroform; soluble in ethanol (26mg/mL), isopropanol, acetone, ethyl acetate; freely soluble in methanol (>100mg/mL), DMF (>100mg/mL); practically insoluble in ether. |
| InChI nøgle | DOQPXTMNIUCOSY-UHFFFAOYSA-N |
| SMIL | CC(C)C(CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C=C2)OC)OC.Cl |
| IUPAC navn | 2-(3,4-dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethylmethylamino]-2-propan-2-ylpentanenitril;hydrochlorid |
| Molekylvægt (g/mol) | 491.069 |
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Produkttitel
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