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Tolfenamic acid, 99+%

Artikelnummer. 15473869
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Regulatorisk: Dette produkt falder ind under Lov om kemiske stoffer og produkter - lovbekendtgørelse nr. 1755 af 22. december 2006. Hvis det er relevant, skal kunden fremskaffe en licens før levering.
Artikelnummer. 15473869 Leverandør Thermo Scientific Alfa Aesar Leverandørnr. J61256.09
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Descripción

NSAID that activates calcium-activated potassium channels | CAS: 13710-19-5 | C14H12ClNO2 | 261.705 g/mol

Tolfenamic acid is a non-steroidal anti-inflammatory agent. It interferes with synthesis of β-amyloid precursor protein, and thus Aβ peptides, by promoting degradation of an essential transcription factor. It inhibits fMLP- and A23187-induced Ca2+ influx in human PMNL with an IC50 value of approximately 20 μM.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Tolfenamic acid is a non-steroidal anti-inflammatory agent. It interferes with synthesis of β-amyloid precursor protein, and thus Aβ peptides, by promoting degradation of an essential transcription factor. It inhibits fMLP- and A23187-induced Ca2+ influx in human PMNL with an IC50 value of approximately 20 µM.

Solubility
Soluble in water (slightly), acetone (∼10 mg/ml), DMSO (52 mg/ml at 25°C), methanol (∼10 mg/ml) and ethanol (50 mg/ml).

Notes
Stable under recommended storage conditions. Incompatible with oxidizing agents.
TRUSTED_SUSTAINABILITY

Identificadores de productos químicos

CAS 13710-19-5
Molekylær formel C14H12ClNO2
Molekylvægt (g/mol) 261.705
MDL nummer MFCD00133865
InChI nøgle YEZNLOUZAIOMLT-UHFFFAOYSA-N
Synonym tolfenamic acid, clotam, n-3-chloro-2-methylphenyl anthranilic acid, 2-3-chloro-2-methylphenyl amino benzoic acid, tolfedine, acido tolfenamico, acide tolfenamique, acidum tolfenamicum, tolfine, n-2-methyl-3-chlorophenyl anthranilic acid
PubChem CID 610479
ChEBI CHEBI:32243
IUPAC navn 2-(3-chloro-2-methylanilino)benzoic acid
SMIL CC1=C(C=CC=C1Cl)NC2=CC=CC=C2C(=O)O

Especificaciones

Kemisk navn eller materiale Tolfenamic acid
Farve White
Mængde 10 g
FN nummer UN2811
Merck Index 14,9513
Opløselighedsinformation Soluble in water (slightly),acetone (∽10mg/ml),DMSO (52mg/ml at 25°C),methanol (∽10mg/ml) and ethanol (50mg/ml).
Formel vægt 261.7
Procent renhed ≥99%
Fysisk form Crystalline Powder

Seguridad y manipulación

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Nombre del producto
  • Tolfenamic acid
 Palabra de advertencia
  • Fare
 Clasificación
  • Akut toksicitet Kategori 3
 Indicaciones de peligro
  • H301-Giftig ved indtagelse.
 Consejos de prudencia
  • P264-Vask grundigt efter brug.
  • P301+P310-I TILFÆLDE AF INDTAGELSE: Ring omgående til en GIFTINFORMATION/læge
 Otros peligros
  • MIXTURE LIST-Contain: Tolfenamic acid

RUO – Research Use Only

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