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Tolbutamide, 98%

Artikelnummer. 11460287
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Artikelnummer. 11460287 Leverandør Thermo Scientific Alfa Aesar Leverandørnr. B21698.09
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Beskrivelse

CAS: 64-77-7 | C12H18N2O3S | 270.347 g/mol

Tolbutamide, have been used in a cDNA microarray assay to probe changes in gene expression in HepG2 cells upon their administration. It has been utilized to counteract insulin activity in a patch-clamp investigation of ATP sensitive K+ channels in mouse pancreatic β-cells. The activity of various biotransformation enzymes in cultured primary rat proximal tubular cells in the presence of tolbutamide and other compounds has been studied.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Tolbutamide, have been used in a cDNA microarray assay to probe changes in gene expression in HepG2 cells upon their administration. It has been utilized to counteract insulin activity in a patch-clamp investigation of ATP sensitive K+ channels in mouse pancreatic β-cells. The activity of various biotransformation enzymes in cultured primary rat proximal tubular cells in the presence of tolbutamide and other compounds has been studied.

Solubility
Soluble in chloroform.

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from oxidizing agent.
TRUSTED_SUSTAINABILITY

Kemiske identifikatorer

CAS 64-77-7
Molekylær formel C12H18N2O3S
Molekylvægt (g/mol) 270.347
MDL nummer MFCD00027169
InChI nøgle JLRGJRBPOGGCBT-UHFFFAOYSA-N
Synonym tolbutamide, orinase, 1-butyl-3-tosylurea, tolbutamid, aglicid, arkozal, artosin, diabetol, dolipol, rastinon
PubChem CID 5505
ChEBI CHEBI:27999
IUPAC navn 1-butyl-3-(4-methylphenyl)sulfonylurea
SMIL CCCCNC(=O)NS(=O)(=O)C1=CC=C(C=C1)C

Tekniske data

Kemisk navn eller materiale Tolbutamide
Smeltepunkt 128°C to 130°C
Mængde 10 g
Beilstein 1984428
Merck Index 14,9507
Opløselighedsinformation Soluble in chloroform.
Formel vægt 270.35
Procent renhed 98%

Sikkerhed og håndtering

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Produktidentifikator
  • Tolbutamide
 Signalord
  • Advarsel
 Farekategori
  • Akut toksicitet Kategori 4
  • Hudsensibilisering Kategori 1
 Faresætning
  • H302-Farlig ved indtagelse.
  • H317-Kan forårsage allergisk hudreaktion.
 Sikkerhedssætning
  • P280-Bær beskyttelseshandsker/beskyttelsestøj/øjenbeskyttelse/ ansigtsbeskyttelse.
  • P301+P330+P331-I TILFÆLDE AF INDTAGELSE: Skyl munden. Fremkald IKKE opkastning.
  • P302+P352-VED KONTAKT MED HUDEN: Vask med rigeligt vand/.
  • P312-I tilfælde af ubehag, ring til en GIFTINFORMATION/læge/ .
  • P333+P313-Ved hudirritation eller udslet: Søg lægehjælp.
 Supplerende oplysninger
  • MIXTURE LIST-Contain: Tolbutamide

RUO – Research Use Only

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