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Telaglenastat, MedChemExpress

Artikelnummer. 16491277
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16491277 50 mg
16455786 100 mg
16435048 10 mg
16487767 5 mg
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Artikelnummer. 16491277 Leverandør Medchem Express Leverandørnr. HY12248

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Beskrivelse

MedChemExpress Telaglenastat (CB-839) is a first-in-class, selective, reversible and orally active glutaminase 1 (GLS1) inhibitor. Telaglenastat selectively inhibits GLS1 splice variants KGA (kidney-type glutaminase) and GAC (glutaminase C) compared to GLS2. The IC50s are 23 nM and 28 nM for endogenous glutaminase in mouse kidney and brain, respectively. Telaglenastat inudces autophagy and has antitumor activity.

Telaglenastat (CB-839) is a first-in-class, selective, reversible and orally active glutaminase 1 (GLS1) inhibitor. Telaglenastat selectively inhibits GLS1 splice variants KGA (kidney-type glutaminase) and GAC (glutaminase C) compared to GLS2. The IC50s are 23 nM and 28 nM for endogenous glutaminase in mouse kidney and brain, respectively. Telaglenastat inudces autophagy and has antitumor activity.

Tekniske data

Kemisk navn eller materiale Telaglenastat
CAS 1439399-58-2
Farve Light Brown
Renhedsgrad noter Research
Molekylær formel C26H24F3N7O3S
Mængde 50 mg
Synonym CB-839
Opløselighedsinformation DMSO : 6.29 mg/mL (11.00 mM; Need ultrasonic)
SMIL O=C(NC1=NN=C(CCCCC2=NN=C(NC(CC3=CC=CC(OC(F)(F)F)=C3)=O)C=C2)S1)CC4=NC=CC=C4
Molekylvægt (g/mol) 571.57
Formel vægt 571.57
Procent renhed 98.0%
Grad Research
Fysisk form Solid
Til brug med (applikation) Cancer-programmed cell death
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Research purposes only

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