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T0901317, MedChemExpress

Artikelnummer. 16495046
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Artikelnummer. Mængde
16495046 100 mg
16444078 10 mg
16400437 50 mg
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Artikelnummer. 16495046 Leverandør Medchem Express Leverandørnr. HY10626

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Beskrivelse

MedChemExpress T0901317 is an orally active and highly selective LXR agonist with an EC50 of 20 nM for LXRα. T0901317 activates FXR with an EC50 of 5 μM. T0901317 is RORα and RORγ dual inverse agonist with Ki values of 132 nM and 51 nM, respectively. T0901317 induces apoptosis and inhibits the development of atherosclerosis in low-density lipoprotein (LDL) receptor-deficient mice.

T0901317 is an orally active and highly selective LXR agonist with an EC50 of 20 nM for LXRα. T0901317 activates FXR with an EC50 of 5 μM. T0901317 is RORα and RORγ dual inverse agonist with Ki values of 132 nM and 51 nM, respectively. T0901317 induces apoptosis and inhibits the development of atherosclerosis in low-density lipoprotein (LDL) receptor-deficient mice.

Tekniske data

Kemisk navn eller materiale T0901317
CAS 293754-55-9
Farve Off-White
Renhedsgrad noter Research
Molekylær formel C17H12F9NO3S
Mængde 100 mg
Opløselighedsinformation DMSO : 100 mg/mL (207.76 mM; Need ultrasonic)
SMIL OC(C(F)(F)F)(C(F)(F)F)C1=CC=C(N(CC(F)(F)F)S(C2=CC=CC=C2)(=O)=O)C=C1
Molekylvægt (g/mol) 481.33
Formel vægt 481.33
Procent renhed 99.8%
Grad Research
Fysisk form Solid
Til brug med (applikation) Cancer-programmed cell death
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Research purposes only

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