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Sitravatinib, MedChemExpress

Artikelnummer. 16489747
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200mg
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Artikelnummer. 16489747 Leverandør Medchem Express Leverandørnr. HY16961

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Beskrivelse

MedChemExpress Sitravatinib (MGCD516) is an orally bioavailable receptor tyrosine kinase (RTK) inhibitor with IC50s of 1.5 nM, 2 nM, 2 nM, 5 nM, 6 nM, 6 nM, 8 nM, 0.5 nM, 29 nM, 5 nM, and 9 nM for Axl, MER, VEGFR3, VEGFR2, VEGFR1, KIT, FLT3, DDR2, DDR1, TRKA, TRKB, respectively. Sitravatinib shows potent single-agent antitumor efficacy and enhances the activity of PD-1 blockade through promoting an antitumor immune microenvironment.

Sitravatinib (MGCD516) is an orally bioavailable receptor tyrosine kinase (RTK) inhibitor with IC50s of 1.5 nM, 2 nM, 2 nM, 5 nM, 6 nM, 6 nM, 8 nM, 0.5 nM, 29 nM, 5 nM, and 9 nM for Axl, MER, VEGFR3, VEGFR2, VEGFR1, KIT, FLT3, DDR2, DDR1, TRKA, TRKB, respectively. Sitravatinib shows potent single-agent antitumor efficacy and enhances the activity of PD-1 blockade through promoting an antitumor immune microenvironment.

Tekniske data

Kemisk navn eller materiale Sitravatinib
CAS 1123837-84-2
Farve Off-White
Renhedsgrad noter Research
Molekylær formel C33H29F2N5O4S
Mængde 5 mg
Synonym MGCD516 MG-516
Opløselighedsinformation DMSO : ≥ 32 mg/mL (50.82 mM)
SMIL O=C(C1(C(NC2=CC=C(F)C=C2)=O)CC1)NC3=CC=C(OC4=C5C(C=C(C6=NC=C(CNCCOC)C=C6)S5)=NC=C4)C(F)=C3
Molekylvægt (g/mol) 629.68
Formel vægt 629.68
Procent renhed 98.2%
Grad Research
Fysisk form Solid
Til brug med (applikation) Cancer-Kinase/protease
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Research purposes only

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