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SC144, MedChemExpress

Artikelnummer. 16466836
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16466836 100 mg
16452767 50 mg
16446688 10 mg
16419247 5 mg
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Artikelnummer. 16466836 Leverandør Medchem Express Leverandørnr. HY15614

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Beskrivelse

MedChemExpress SC144 is a first-in-class, orally active gp130 (IL6-beta) inhibitor. SC144 binds gp130, induces gp130 phosphorylation (S782) and deglycosylation, abrogates Stat3 phosphorylation and nuclear translocation, and further inhibits the expression of downstream target genes. SC144 shows potent inhibition of gp130 ligand-triggered signaling. SC144 induces apoptosis in human ovarian cancer cells.

SC144 is a first-in-class, orally active gp130 (IL6-beta) inhibitor. SC144 binds gp130, induces gp130 phosphorylation (S782) and deglycosylation, abrogates Stat3 phosphorylation and nuclear translocation, and further inhibits the expression of downstream target genes. SC144 shows potent inhibition of gp130 ligand-triggered signaling. SC144 induces apoptosis in human ovarian cancer cells.

Tekniske data

Kemisk navn eller materiale SC144
CAS 895158-95-9
Farve Yellow
Renhedsgrad noter Research
Molekylær formel C16H11FN6O
Mængde 100 mg
Opløselighedsinformation DMSO : 16.67 mg/mL (51.72 mM; Need ultrasonic)
SMIL O=C(C1=NC=CN=C1)NNC2=NC3=C(N4C2=CC=C4)C=CC(F)=C3
Molekylvægt (g/mol) 322.3
Formel vægt 322.3
Procent renhed 98.6%
Grad Research
Fysisk form Solid
Til brug med (applikation) Cancer-Kinase/protease
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Research purposes only

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