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RN-1734, MedChemExpress

Artikelnummer. 16483917
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16483917 50 mg
16450458 5 mg
16427776 100 mg
16417998 10 mg
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Artikelnummer. 16483917 Leverandør Medchem Express Leverandørnr. HY19975

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Beskrivelse

MedChemExpress RN-1734 is selective antagonist of the TRPV4 channel, completely antagonizes 4αPDD-mediated activation of TRPV4 with comparable, low micromolar IC50s for all three species (hTRPV4: 2.3 μM, mTRPV4: 5.9 μM, rTRPV4: 3.2 μM). RN-1734 clearly decreases the production of tumor necrosis factor α (TNF-α) and interleukin 1β (IL-1β) without altering the number of olig2-positive cells.

RN-1734 is selective antagonist of the TRPV4 channel, completely antagonizes 4αPDD-mediated activation of TRPV4 with comparable, low micromolar IC50s for all three species (hTRPV4: 2.3 μM, mTRPV4: 5.9 μM, rTRPV4: 3.2 μM). RN-1734 clearly decreases the production of tumor necrosis factor α (TNF-α) and interleukin 1β (IL-1β) without altering the number of olig2-positive cells.

Tekniske data

Kemisk navn eller materiale RN-1734
CAS 946387-07-1
Farve White
Renhedsgrad noter Research
Molekylær formel C14H22Cl2N2O2S
Mængde 50 mg
Opløselighedsinformation DMSO : 25 mg/mL (70.76 mM; ultrasonic and warming and heat to 60°C)
SMIL O=S(C1=CC=C(Cl)C=C1Cl)(N(C(C)C)CCNC(C)C)=O
Molekylvægt (g/mol) 353.31
Formel vægt 353.31
Procent renhed 98.99%
Grad Research
Fysisk form Solid
Til brug med (applikation) Neuroscience-Neuromodulation
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Research purposes only

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