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R406, MedChemExpress

Artikelnummer. 16474968
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16474968 10 mg
16441217 50 mg
16437707 5 mg
16425746 100 mg
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Artikelnummer. 16474968 Leverandør Medchem Express Leverandørnr. HY12067

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Beskrivelse

MedChemExpress R406 is an orally available and competitive Syk/FLT3 inhibitor for ATP binding with a Ki of 30 nM, potently inhibits Syk kinase activity in vitro with an IC50 of 41 nM, measured at an ATP concentration corresponding to its Km value. R406 reduces immune complex-mediated inflammation. R406 also inhibits Lyn (IC50=63 nM) and Lck (IC50=37 nM).

R406 is an orally available and competitive Syk/FLT3 inhibitor for ATP binding with a Ki of 30 nM, potently inhibits Syk kinase activity in vitro with an IC50 of 41 nM, measured at an ATP concentration corresponding to its Km value. R406 reduces immune complex-mediated inflammation. R406 also inhibits Lyn (IC50=63 nM) and Lck (IC50=37 nM).

Tekniske data

Kemisk navn eller materiale R406
CAS 841290-81-1
Farve Earth Yellow
Renhedsgrad noter Research
Molekylær formel C28H29FN6O8S
Mængde 10 mg
Opløselighedsinformation DMSO : ≥ 61 mg/mL (97.04 mM) ∣H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)
SMIL COC1=CC(NC2=NC(NC3=NC(N4)=C(C=C3)OC(C)(C)C4=O)=C(C=N2)F)=CC(OC)=C1OC.OS(C5=CC=CC=C5)(=O)=O
Molekylvægt (g/mol) 628.63
Formel vægt 628.63
Procent renhed 96.67%
Grad Research
Fysisk form Solid
Til brug med (applikation) Cancer-Kinase/protease
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Research purposes only

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