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Pyr10, MedChemExpress

Artikelnummer. 16450228
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Mængde:
5 mg
10 mg
50 mg
Pakningsstørrelse:
10mg
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16450228 5 mg -
16417768 10 mg 10mg
16403737 50 mg -
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Artikelnummer. 16450228 Leverandør Medchem Express Leverandørnr. HY19408

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Beskrivelse

MedChemExpress Pyr10 is a pyrazole derivative and a selective TRP cation 3 (TRPC3) inhibitor. Pyr10 inhibits Ca2+ influx in carbachol-stimulated TRPC3-transfected HEK293 cells with an IC50 of 0.72 μM (IC50 of 13.08 μM for store operated Ca2+ entry in BRL-2H3 cells). Pyr10 has the ability to distinguish between receptor-operated TRPC3 and native stromal interaction molecule 1 (STIM1)/Orai1 channels.

Pyr10 is a pyrazole derivative and a selective TRP cation 3 (TRPC3) inhibitor. Pyr10 inhibits Ca2+ influx in carbachol-stimulated TRPC3-transfected HEK293 cells with an IC50 of 0.72 μM (IC50 of 13.08 μM for store operated Ca2+ entry in BRL-2H3 cells). Pyr10 has the ability to distinguish between receptor-operated TRPC3 and native stromal interaction molecule 1 (STIM1)/Orai1 channels.

Tekniske data

Kemisk navn eller materiale Pyr10
CAS 1315323-00-2
Farve Off-White
Renhedsgrad noter Research
Molekylær formel C18H13F6N3O2S
Mængde 5 mg
Opløselighedsinformation DMSO : 100 mg/mL (222.53 mM; Need ultrasonic)
SMIL O=S(C1=CC=C(C)C=C1)(NC2=CC=C(N3N=C(C(F)(F)F)C=C3C(F)(F)F)C=C2)=O
Molekylvægt (g/mol) 449.37
Formel vægt 449.37
Procent renhed 97.52%
Grad Research
Fysisk form Solid
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Research purposes only

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