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Prexasertib, MedChemExpress

Artikelnummer. 16433596
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Artikelnummer. 16433596 Leverandør Medchem Express Leverandørnr. HY18174

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Beskrivelse

MedChemExpress Prexasertib (LY2606368) is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a Ki of 0.9 nM and an IC50 of 50=8 nM) and RSK1 (IC50=9 nM). Prexasertib causes double-stranded DNA breakage and replication catastrophe resulting in apoptosis. Prexasertib shows potent anti-tumor activity.

Prexasertib (LY2606368) is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a Ki of 0.9 nM and an IC50 of 50=8 nM) and RSK1 (IC50=9 nM). Prexasertib causes double-stranded DNA breakage and replication catastrophe resulting in apoptosis. Prexasertib shows potent anti-tumor activity.

Tekniske data

Kemisk navn eller materiale Prexasertib
CAS 1234015-52-1
Farve Light Yellow
Renhedsgrad noter Research
Molekylær formel C18H19N7O2
Mængde 25 mg
Synonym LY2606368
Opløselighedsinformation DMSO : 16.67 mg/mL (45.62 mM; Need ultrasonic)
SMIL NCCCOC(C=CC=C1OC)=C1C2=CC(NC3=NC=C(C#N)N=C3)=NN2
Molekylvægt (g/mol) 365.39
Formel vægt 365.39
Procent renhed 98.03%
Grad Research
Fysisk form Solid
Til brug med (applikation) Cancer-Kinase/protease
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Research purposes only

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