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PIM-447 dihydrochloride, MedChemExpress

Artikelnummer. 16493697
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16493697 50 mg
16470188 5 mg
16447728 10 mg
16431799 1 mg
16407596 100 mg
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Artikelnummer. 16493697 Leverandør Medchem Express Leverandørnr. HY19322B

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Beskrivelse

MedChemExpress PIM447 dihydrochloride (LGH447 dihydrochloride) is a potent, orally available, and selective pan-PIM kinase inhibitor, with Ki values of 6, 18, and 9 pM for PIM1, PIM2, and PIM3, respectively. PIM447 dihydrochloride displays dual antimyeloma and bone-protective effects. PIM447 dihydrochloride induces apoptosis.

PIM447 dihydrochloride (LGH447 dihydrochloride) is a potent, orally available, and selective pan-PIM kinase inhibitor, with Ki values of 6, 18, and 9 pM for PIM1, PIM2, and PIM3, respectively. PIM447 dihydrochloride displays dual antimyeloma and bone-protective effects. PIM447 dihydrochloride induces apoptosis.

Tekniske data

Kemisk navn eller materiale PIM-447 dihydrochloride
CAS 1820565-69-2
Farve Off-White
Renhedsgrad noter Research
Molekylær formel C24H25Cl2F3N4O
Mængde 50 mg
Synonym LGH447 dihydrochloride
Opløselighedsinformation H2O : 50 mg/mL (97.39 mM; Need ultrasonic) ∣DMSO : ≥ 46.7 mg/mL (90.97 mM)
SMIL O=C(C1=NC(C2=C(F)C=CC=C2F)=C(F)C=C1)NC3=C([C@H]4C[C@@H](N)C[C@@H](C)C4)C=CN=C3.Cl.Cl
Molekylvægt (g/mol) 513.38
Formel vægt 513.38
Procent renhed 98.25%
Grad Research
Fysisk form Solid
Til brug med (applikation) Cancer-Kinase/protease
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Research purposes only

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