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PF-543 Citrate, MedChemExpress

Artikelnummer. 16499087
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16499087 5 mg
16466508 10 mg
16442607 50 mg
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Artikelnummer. 16499087 Leverandør Medchem Express Leverandørnr. HY15425A

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Beskrivelse

MedChemExpress PF-543 Citrate (Sphingosine Kinase 1 Inhibitor II Citrate) is a potent, selective, reversible and sphingosine-competitive SPHK1 inhibitor with an IC50 of 2 nM and a Ki of 3.6 nM. PF-543 Citrate is >100-fold selectivity for SPHK1 over SPHK2. PF-543 Citrate is an effective potent inhibitor of sphingosine 1-phosphate (S1P) formation in whole blood with an IC50 of 26.7 nM. PF-543 Citrate induces apoptosis, necrosis, and autophagy.

PF-543 Citrate (Sphingosine Kinase 1 Inhibitor II Citrate) is a potent, selective, reversible and sphingosine-competitive SPHK1 inhibitor with an IC50 of 2 nM and a Ki of 3.6 nM. PF-543 Citrate is >100-fold selectivity for SPHK1 over SPHK2. PF-543 Citrate is an effective potent inhibitor of sphingosine 1-phosphate (S1P) formation in whole blood with an IC50 of 26.7 nM. PF-543 Citrate induces apoptosis, necrosis, and autophagy.

Tekniske data

Kemisk navn eller materiale PF-543 Citrate
CAS 1415562-83-2
Farve Light Yellow
Renhedsgrad noter Research
Molekylær formel C33H39NO11S
Mængde 5 mg
Synonym Sphingosine Kinase 1 Inhibitor II Citrate
Opløselighedsinformation DMSO : ≥ 100 mg/mL (152.04 mM) ∣H2O : 50 mg/mL (76.02 mM; Need ultrasonic)
SMIL OC(C(O)=O)(CC(O)=O)CC(O)=O.O=S(C1=CC=CC=C1)(CC2=CC(C)=CC(OCC3=CC=C(CN4[C@@H](CO)CCC4)C=C3)=C2)=O
Molekylvægt (g/mol) 657.73
Formel vægt 657.73
Procent renhed 98.35%
Grad Research
Fysisk form Solid
Til brug med (applikation) Cancer-Kinase/protease
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Research purposes only

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