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Gibco™ PeproGMP® Human FGF-basic (FGF-2/bFGF) Recombinant Protein, PeproTech®

Artikelnummer. 30275723
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Mængde:
1 mg
100 μg
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30275723 100 μg
30276681 1 mg
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Artikelnummer. 30275723 Leverandør Gibco™ Leverandørnr. GMP10018B100UG

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Beskrivelse

Recombinant Protein

Additional product information and specifications are provided on the Certificate of Analysis. All PeproGMP® products are manufactured using animal-derived component free materials. Product Description/Intended Use: PeproTech GMP recombinant proteins are manufactured for use as ancillary materials by applying applicable principles of GMP and quality control requirements from USP (United States Pharmacopeia) Chapter 1043 Ancillary Materials for Cell, Gene, and Tissue-Engineered Products. Product use statement: For research use or further manufacturing. Not for diagnostic use or direct administration into humans or animals.

FGF2 (FGFb, fibroblast growth factor basic) belongs to the fibroblast growth factor (FGF) family, and interacts with high-affinity transmembrane receptors to influence cell proliferation and tissue neovascularization. FGF2 exists as five isoforms with distinct intracellular localizations and functions. The 18 kDa isoform is predominantly cytosolic and acts through cell surface receptors, whereas the 22, 22.5, 24 and 34 kDa isoforms are nuclear and may signal independent of transmembrane receptor pathways. In humans, the gene is located on the q arm of chromosome 4. FGF2 has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for FGF2 contains multiple polyadenylation sites, and is alternatively translated from non-AUG and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. Diseases associated with FGF2 dysfunction include Kaposi Sarcoma and corneal neovascularization.
TRUSTED_SUSTAINABILITY

Tekniske data

Adgangsnummer P09038
Til brug med (applikation) Control, Western Blot Control, Bioactivity
Format Lyophilized
Formulering Protein with no preservative
Gen-id (Entrez) 2247
Molekylvægt (g/mol) 17.2 kDa
Navn PeproGMP™ Human FGF-basic (FGF-2/bFGF)
Oprensningsmetode Purified
Mængde 100 μg
Opbevaringskrav -20°C or -80°C if preferred
Regulatorisk status GMP
Endotoksin koncentration ≤0.1 EU/μg
Gene Alias Basic fibroblast growth factor; basic fibroblast growth factor bFGF; bFGF; FGF; fgf basic; Fgf2; Fgf-2; Fgfb; FGF-b; Fibroblast growth factor; fibroblast growth factor 2; fibroblast growth factor 2 (basic); Fibroblast growth factor basic; HBGF-2; Heparin-binding growth factor 2; H-FGF-b-147; H-FGF-b-154; M-FGF-b; Prostatic growth factor; prostatropin
Fælles navn FGF2
Gen symbol FGF2
Biologisk aktivitet Determined by the proliferation of mouse Balb/c 3T3 cells. PeproGMP Recombinant Human FGF-basic has been tested against the WHO standard NIBSC 90/712.
Produkttype Protein
Konjugeret Unconjugated
Rekombinant Recombinant
Sekvens AAGSITTLPA LPEDGGSGAF PPGHFKDPKR LYCKNGGFFL RIHPDGRVDG VREKSDPHIK LQLQAEERGV VSIKGVCANR YLAMKEDGRL LASKCVTDEC FFFERLESNN YNTYRSRKYT SWYVALKRTG QYKLGSKTGP GQKAILFLPM SAKS
Indhold og opbevaring -20°Cor to +80°C if preferred
Aktivitet Determined by the proliferation of mouse Balb/c 3T3 cells. PeproGMP Recombinant Human FGF-basic has been tested against the WHO standard NIBSC 90/712. Find the International Unit (IU) value <a href='https://www.thermofisher.com/us/en/home/life-science/cell-culture/cell-culture-learning-center/recombinant-protein-information/international-units.html'>here</a>.
Udtrykssystem E. coli
Form Lyophilized
Produktlinje PeproGMP
Renhed eller kvalitetsklasse ≥ 95% by SDS-PAGE gel and HPLC analyses.
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