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Tocris Bioscience™ MZ 1
(+)-JQ1 based Degrader (PROTAC™) that selectively degrades BRD4
Brand: Tocris Bioscience™ 6154/5
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Beskrivelse
Cell penetrant Degrader (PROTAC®) compound based on (+)-JQ1 (Cat.No. 4499) conjugated to a von Hippel-Lindau (VHL) ligand. MZ 1 retains high affinity for BRD2, BRD3 and BRD4 bromodomains (Kd = 13-60 nM) but induces preferential degradation of BRD4 over BRD2 and BRD3 (DC50 values for degradation of BRD4 are 8 and 23 nM in H661 and H838 cells, respectively). Exhibits potent cytotoxicity and antiproliferative effects in AML cell lines (pEC50 = 7.6 in Mv4-11 cells).Negative control cis MZ 1 also available.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Tekniske data
| (+)-JQ1 based PROTAC that selectively degrades BRD4 in cells | |
| 1797406-69-9 | |
| 1002.64g/mol | |
| Bromodomain Inhibitors |
| Bromodomain | |
| C49H60ClN9O8S2 | |
| Store at -20°C | |
| 5 mg |
Produkttitel
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