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Merestinib, MedChemExpress

Artikelnummer. 16486786
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Artikelnummer. 16486786 Leverandør Medchem Express Leverandørnr. HY15514

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Beskrivelse

MedChemExpress Merestinib (LY2801653) is a potent, orally bioavailable c-Met inhibitor (Ki=2 nM) with anti-tumor activities. Merestinib (LY2801653) also has potent activity against MST1R (IC50=11 nM), FLT3 (IC50=7 nM), AXL (IC50=2 nM), MERTK (IC50=10 nM), TEK (IC50=63 nM), ROS1, DDR1/2 (IC50=0.1/7 nM) and MKNK1/2 (IC50=7 nM).

Merestinib (LY2801653) is a potent, orally bioavailable c-Met inhibitor (Ki=2 nM) with anti-tumor activities. Merestinib (LY2801653) also has potent activity against MST1R (IC50=11 nM), FLT3 (IC50=7 nM), AXL (IC50=2 nM), MERTK (IC50=10 nM), TEK (IC50=63 nM), ROS1, DDR1/2 (IC50=0.1/7 nM) and MKNK1/2 (IC50=7 nM).

Tekniske data

Kemisk navn eller materiale Merestinib
CAS 1206799-15-6
Farve White
Renhedsgrad noter Research
Molekylær formel C30H22F2N6O3
Mængde 100 mg
Synonym LY2801653
Opløselighedsinformation DMSO : ≥ 32 mg/mL (57.92 mM)
SMIL O=C(C1=CC=C(C)N(C2=CC=C(F)C=C2)C1=O)NC3=CC=C(OC4=CC5=C(N(C)N=C5)C=C4C6=CNN=C6)C(F)=C3
Molekylvægt (g/mol) 552.53
Formel vægt 552.53
Procent renhed 98.21%
Grad Research
Fysisk form Solid
Til brug med (applikation) Cancer-Kinase/protease
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Research purposes only

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