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Merestinib dihydrochloride, MedChemExpress

Artikelnummer. 16496786
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Artikelnummer. 16496786 Leverandør Medchem Express Leverandørnr. HY15514A

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Beskrivelse

MedChemExpress Merestinib dihydrochloride (LY2801653 dihydrochloride) is a potent, orally bioavailable c-Met inhibitor (Ki=2 nM) with anti-tumor activities. Merestinib dihydrochloride also has potent activity against MST1R (IC50=11 nM), FLT3 (IC50=7 nM), AXL (IC50=2 nM), MERTK (IC50=10 nM), TEK (IC50=63 nM), ROS1, DDR1/2 (IC50=0.1/7 nM) and MKNK1/2 (IC50=7 nM).

Merestinib dihydrochloride (LY2801653 dihydrochloride) is a potent, orally bioavailable c-Met inhibitor (Ki=2 nM) with anti-tumor activities. Merestinib dihydrochloride also has potent activity against MST1R (IC50=11 nM), FLT3 (IC50=7 nM), AXL (IC50=2 nM), MERTK (IC50=10 nM), TEK (IC50=63 nM), ROS1, DDR1/2 (IC50=0.1/7 nM) and MKNK1/2 (IC50=7 nM).

Tekniske data

Kemisk navn eller materiale Merestinib dihydrochloride
CAS 1206801-37-7
Farve Pale Yellow
Renhedsgrad noter Research
Molekylær formel C30H24Cl2F2N6O3
Mængde 100 mg
Synonym LY2801653 dihydrochloride
Opløselighedsinformation DMSO : ≥ 100 mg/mL (159.88 mM)
SMIL [H]Cl.[H]Cl.O=C(C1=CC=C(C)N(C2=CC=C(F)C=C2)C1=O)NC3=CC=C(OC4=CC5=C(N(C)N=C5)C=C4C6=CNN=C6)C(F)=C3
Molekylvægt (g/mol) 625.45
Formel vægt 625.45
Procent renhed 98.12%
Grad Research
Fysisk form Solid
Til brug med (applikation) Cancer-Kinase/protease
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Research purposes only

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