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LY2886721, MedChemExpress

Artikelnummer. 16485578
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16485578 10 mg
16468277 5 mg
16456126 100 mg
16451747 50 mg
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Artikelnummer. 16485578 Leverandør Medchem Express Leverandørnr. HY13240

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Beskrivelse

MedChemExpress LY2886721 is a potent, selective and orally active beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC50 of 20.3 nM for recombinant human BACE1. LY2886721 is selectivity against cathepsin D, pepsin, and renin, but lacking selectivity against BACE2 (IC50 of 10.2 nM). LY2886721 can across blood-brain barrier and has the potential for Alzheimer's disease treatment.

LY2886721 is a potent, selective and orally active beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC50 of 20.3 nM for recombinant human BACE1. LY2886721 is selectivity against cathepsin D, pepsin, and renin, but lacking selectivity against BACE2 (IC50 of 10.2 nM). LY2886721 can across blood-brain barrier and has the potential for Alzheimer's disease treatment.

Tekniske data

Kemisk navn eller materiale LY2886721
CAS 1262036-50-9
Farve White
Renhedsgrad noter Research
Molekylær formel C18H16F2N4O2S
Mængde 10 mg
Opløselighedsinformation DMSO : 20 mg/mL (51.23 mM; Need ultrasonic) ∣H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)
SMIL FC1=CN=C(C=C1)C(NC2=CC=C(C([C@@]34[C@]([H])(CSC(N)=N4)COC3)=C2)F)=O
Molekylvægt (g/mol) 390.41
Formel vægt 390.41
Procent renhed 99.42%
Grad Research
Fysisk form Solid
Til brug med (applikation) Neuroscience-Neurodegeneration
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Research purposes only

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