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Linifanib, MedChemExpress

Artikelnummer. 16481316
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Mængde:
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500 mg
Pakningsstørrelse:
200mg
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16481316 200 mg 200mg
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16457866 100 mg -
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16401926 500 mg -
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Artikelnummer. 16481316 Leverandør Medchem Express Leverandørnr. HY50751

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Beskrivelse

MedChemExpress Linifanib (ABT-869) is a potent and orally active multi-target inhibitor of VEGFR and PDGFR family with IC50s of 4, 3, 66, and 4 nM for KDR, FLT1, PDGFRβ, and FLT3, respectively. Linifanib shows prominent antitumor activity. Linifanib has much less activity against unrelated RTKs, soluble tyrosine kinases, or serine/threonine kinases. Linifanib is a specific miR-10b inhibitor that blocks miR-10b biogenesis.

Linifanib (ABT-869) is a potent and orally active multi-target inhibitor of VEGFR and PDGFR family with IC50s of 4, 3, 66, and 4 nM for KDR, FLT1, PDGFRβ, and FLT3, respectively. Linifanib shows prominent antitumor activity. Linifanib has much less activity against unrelated RTKs, soluble tyrosine kinases, or serine/threonine kinases. Linifanib is a specific miR-10b inhibitor that blocks miR-10b biogenesis.

Tekniske data

Kemisk navn eller materiale Linifanib
CAS 796967-16-3
Farve Off-White
Renhedsgrad noter Research
Molekylær formel C21H18FN5O
Mængde 200 mg
Synonym ABT-869 AL-39324
Opløselighedsinformation DMSO : 13.16 mg/mL (35.06 mM; Need ultrasonic)
SMIL O=C(NC1=CC=C(C2=C3C(N)=NNC3=CC=C2)C=C1)NC4=C(C=CC(C)=C4)F
Molekylvægt (g/mol) 375.4
Formel vægt 375.4
Procent renhed 98.3%
Grad Research
Fysisk form Powder
Til brug med (applikation) Cancer-Kinase/protease
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Research purposes only

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