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ICA-121431, MedChemExpress

Artikelnummer. 16463217
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Mængde:
10 mg
50 mg
Pakningsstørrelse:
50mg
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16463217 50 mg 50mg
16457198 10 mg -
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Artikelnummer. 16463217 Leverandør Medchem Express Leverandørnr. HY16787

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Beskrivelse

MedChemExpress ICA-121431 is a nanomolar potent and broad-spectrum voltage-gated sodium channel (Nav) blocker, shows equipotent selectivity for human Nav1.1 and Nav1.3 subtypes with IC50 values of 13 nM and 23 nM, respectively. ICA-121431 shows less potent inhibition of Nav1.2 (IC50=240 nM) and 1,000 fold selectivity against Nav1.4, Nav1.6, and the TTX-resistant human Nav1.5 and Nav1.8 channels (IC50s >10 μM).

ICA-121431 is a nanomolar potent and broad-spectrum voltage-gated sodium channel (Nav) blocker, shows equipotent selectivity for human Nav1.1 and Nav1.3 subtypes with IC50 values of 13 nM and 23 nM, respectively. ICA-121431 shows less potent inhibition of Nav1.2 (IC50=240 nM) and 1,000 fold selectivity against Nav1.4, Nav1.6, and the TTX-resistant human Nav1.5 and Nav1.8 channels (IC50s >10 μM).

Tekniske data

Kemisk navn eller materiale ICA-121431
CAS 313254-51-2
Farve Off-White
Renhedsgrad noter Research
Molekylær formel C23H19N3O3S2
Mængde 50 mg
Opløselighedsinformation DMSO : ≥ 44 mg/mL (97.88 mM)
SMIL O=C(NC1=CC=C(S(NC2=NC=CS2)(=O)=O)C=C1)C(C3=CC=CC=C3)C4=CC=CC=C4
Molekylvægt (g/mol) 449.55
Formel vægt 449.55
Procent renhed 98.45%
Grad Research
Fysisk form Solid
Til brug med (applikation) COVID-19-immunoregulation
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Research purposes only

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