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Gibco™ Human/Mouse/Rat BDNF Recombinant Protein, PeproTech® Artikelnummer.: 17834733
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Gibco™ Human/Mouse/Rat BDNF Recombinant Protein, PeproTech®

Artikelnummer. 17834733
10 μg, 10µg
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Mængde:
1 mg
10 μg
100 μg
2 μg
250 μg
50 μg
500 μg
Pakningsstørrelse:
100µg
10µg
50µg
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Artikelnummer. 17834733

Brand: Gibco™ 4500210UG

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Beskrivelse

Recombinant Protein

Recombinant Human/Murine/Rat BDNF is a 27.0 kDa homodimer of two 120 amino acid subunits linked by strong non-covalent interactions. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

BDNF (Brain-Derived Neurotrophic Factor) is a member of the neurotrophin family. BDNF is synthesized as pre-proBDNF, followed by cleavage to proBDNF. Although further processing generates the mature, 14 kDa protein, pro-BDNF is biologically active and is secreted in synaptic vesicles along with the mature form. BDNF is widely expressed in the central nervous system and acts in an autocrine and paracrine manner on several classes of neurons. Signaling occurs mainly through the tyrosine kinase receptor TrkB, although binding to the lower-affinity receptor, p75-NTR, has also been demonstrated. BDNF promotes neuronal survival and differentiation and has been shown to play a critical role in memory formation and synaptic regulation. BDNF is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of BDNF is reduced in both Alzheimer's and Huntington disease patients, and may also play a role in the regulation of stress response and in the biology of mood disorders.
TRUSTED_SUSTAINABILITY

Tekniske data

Adgangsnummer P21237, P23363, P23560
Til brug med (applikation) ELISA, Functional Assay, Western Blot
Formulering protein with no preservative
Gen-id (Entrez) 12064, 24225, 627
Molekylvægt (g/mol) 27 kDa
Navn Human/Mouse/Rat BDNF
Mængde 10 μg
Kilde E. coli
Regulatorisk status RUO
Endotoksin koncentration <1 EU/ μg
Gene Alias abrineurin; ANON2; anorexia BDNF; Bdnf; BDNF precursor form; bdnf protein; brain derived neurothrophic factor; brain derived neurotrophic factor; brain-derived neurotrophic factor; BULN2; H-BDNF; neurotrophin; ProBDNF
Fælles navn BDNF
Gen symbol BDNF
Biologisk aktivitet Determined by its ability to bind recombinant human TrkB Fc Chimera in a functional ELISA.
Konjugeret Unconjugated
Rekombinant Recombinant
Sekvens MHSDPARRGE LSVCDSISEW VTAADKKTAV DMSGGTVTVL EKVPVSKGQL KQYFYETKCN PMGYTKEGCR GIDKRHWNSQ CRTTQSYVRA LTMDSKKRIG WRFIRIDTSC VCTLTIKRGR
Indhold og opbevaring -20°C
Udtrykssystem E. coli
Form Lyophilized
Renhed eller kvalitetsklasse ≥ 98% by SDS-PAGE gel and HPLC analyses.
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