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Gibco™ Human GDNF Recombinant Protein

Artikelnummer. 10679963 Shop alle Gibco produkter
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Mængde:
1 mg
10 μg
100 μg
5 μg
Pakningsstørrelse:
Hver
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Artikelnummer. Mængde Pakningsstørrelse
10679963 10 μg Hver
10641504 100 μg Hver
10737683 1 mg Hver
10110633 5 μg Hver
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Artikelnummer. 10679963 Leverandør Gibco™ Leverandørnr. PHC7045
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Beskrivelse

Recombinant Protein

Carrier-Free Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute lyophilized human GDNF in sterile, distilled water to 0.1-0.5 mg/mL. These stock solutions should be apportioned into working aliquots and stored at ≤-20°C. Further dilution should be made in medium or buffered solution containing carrier protein, such as PBS with 0.1% BSA. Storage: Lyophilized human GDNF should be stored at 2°C to 8°C, preferably desiccated. Store reconstituted human GDNF at ≤-20°C (not in a frost-free freezer). Keep freeze-thaw cycles to a minimum.

GDNF is a glycosylated, disulfide-bonded homodimer molecule. It was first discovered as a potent survival factor for midbrain dopaminergic neurons and was then shown to rescue these neurons in animal models of Parkinson's disease. GDNF is about 100 times more efficient survival factor for spinal motor neurons than the neurotrophins. GDNF is a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.
TRUSTED_SUSTAINABILITY

Tekniske data

Adgangsnummer P39905
Til brug med (applikation) Bioactivity
Formulering Protein with no preservative
Gen-id (Entrez) 2668
Molekylvægt (g/mol) 30.1 kDa
Navn Human GDNF
Oprensningsmetode Purified
Mængde 10 μg
Opbevaringskrav 4°C
Regulatorisk status RUO
Endotoksin koncentration <0.1 ng/μg
Gene Alias AI385739; Astrocyte-derived trophic factor; ATF; ATF1; ATF2; Gdnf; glial cell derived neurotrophic factor; glial cell line derived neurotrophic factor; Glial cell line derived neutrophic factor; glial cell line-derived neurotrophic factor; gndf; HFB1-GDNF; hGDNF; H-GDNF; HSCR3; mGDNF; neurotrophic factor
Fælles navn GDNF
Gen symbol GDNF
Biologisk aktivitet ED50 ≤ 10 n/mL; determined by the dose-dependent neurite outgrowth of PC-12 cells in the presence of soluble GFR-alpha.
Produkttype Protein
Konjugeret Unconjugated
Arter Human
Rekombinant Recombinant
Sekvens SPDKQMAVLP RRERNRQAAA ANPENSRGKG RRGQRGKNRG CVLTAIHLNV TDLGLGYETK EELIFRYCSG SCDAAETTYD KILKNLSRNR RLVSDKVGQA CCRPIAFDDD LSFLDDNLVY HILRKHSAKR CGCI
Indhold og opbevaring 4°C
Klassifikation Carrier-Free
Aktivitet ED50 ≤ 10 n/mL; determined by the dose-dependent neurite outgrowth of PC-12 cells in the presence of soluble GFR-alpha.
Endotoksin niveau <0.1 ng/μg
Forsendelsestilstand Approved for shipment on Wet or Dry Ice
Udtrykssystem E. coli
Protein familie Growth Factors & Receptors
Protein form Recombinant, Ligand
Form Lyophilized
Protein undertype Neurotrophic Factors
Forskningskategori Neurobiology, Stem Cell Research, Differentiation
Produktlinje Gibco
Renhed eller kvalitetsklasse >98% by SDS-PAGE
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